Dartmouth Digital Library Program

Thumbnail

Title

Subject

Description

Collection

Molecular mechanisms of estrogen receptor regulation and signaling in human monocytes and macrophages.
Estradiol -- Physiological effect. Estrogen -- Receptors -- Regulation. Macrophages. Monocytes. Cellular signal transduction. Tumor necrosis factor. NF-kappa B (DNA-binding protein) Endometrium -- Immunology. Endometrium -- Physiology.
Sexual dimorphism in immune responses suggests that sex steroid hormones are involved in modulating immune mechanisms in vivo . Sepsis-related mortality rates increase after menopause, implicating 17ß-estradiol (estradiol) as an important factor...
Dartmouth Dissertations

NK cells in the female reproductive tract; biology and protection against HIV-1.
Killer cells. Generative organs, Female -- Immunology. HIV infections -- Immunological aspects. Cellular immunity.
Natural killer (NK) cells are innate immune cells which have been shown to kill tumors and cells infected with viruses. This knowledge however is based on studies carried out with natural killer cells isolated from blood. The female reproductive...
Dartmouth Dissertations

ID4 promotes the growth of glioblastoma multiforme by mediating MGP-enhanced angiogenesis.
Glioblastoma multiforme. DNA-binding proteins. Transcription factors. Extracellular matrix proteins. Neovascularization.
ID proteins are naturally occurring dominant negative HLH-transcription factors that are highly expressed during development but generally not expressed in adult tissue except for selected cell types and some stem cells. Also, aberrant expression...
Dartmouth Dissertations

Molecular characterization of the TCP biogenesis apparatus in Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. Pili (Microbiology). Cholera -- Pathogenesis. Proteins -- Secretion.
Vibrio cholerae is a water-borne, Gram negative enteropathogen that causes the gastrointestinal disorder, cholera, in humans. A critical step in cholera pathogenesis is the attachment and colonization of intestinal cells, and the formation of...
Dartmouth Dissertations

Regeneration of neuromuscular connections from allotransplanted ganglia in the crayfish.
Ganglia, Sensory -- Transplantation. ; Central nervous system -- Regeneration. ; Procambarus clarkii -- Nervous system. ; Neurons -- Innervation. ; Synapses.
Dartmouth Dissertations

TGF-beta1 regulation of Th1 development and autoimmunity.
Transforming growth factors-beta. ; Th1 cells. ; Transcription factors. ; Autoimmunity. ; Cytokines. ; Immune response -- Regulation. ; T cells. ; CD4-Positive T-Lymphocytes -- immunology.
Dartmouth Dissertations

Regulation of ENaC expression by corticosteroids and SGK1 in cortical collection duct cells and mammary epithelial cells.
Sodium channels. Adrenocortical hormones. Protein kinases. Epithelial cells. Mammary glands. Sgk protein.
Regulation of transepithelial sodium transport by corticosteroids occurs in two phases: early and delayed. The early phase involves the activation and translocation of pre-existing epithelial sodium channels (ENaC); whereas, the delayed phase...
Dartmouth Dissertations

Unraveling mechanisms underlying myeloid-derived suppressor cell orchestration of ovarian cancer progression
Suppressor cells -- Cellular immunity. -- Interleukin-10 -- Pathophysiology -- Ovaries -- Cancer -- Immunological aspects. -- Myeloid cells -- immunology -- Ovarian Neoplasms -- immunology.
Dartmouth Dissertations

Regulation of dendritic cell functions by human uterine epithelial cells: Implications for HIV-1 infection of the endometrium.
Dendritic cells. Uterus -- Immunology. Epithelium -- Immunology. Epithelial cells. HIV infections -- Molecular aspects.
The human female reproductive tract (FRT) maintains a state of immune tolerance to spermatozoa and fetal allografts, while retaining the capacity to respond to a number of sexually transmitted infections (STIs) including human immunodeficiecy virus...
Dartmouth Dissertations

14-3-3 sigma modulates pancreatic cancer cell survival and invasiveness.
Pancreas -- Cancer -- Pathophysiology. Pancreatic duct -- Pathophysiology. Proteins -- Pathophysiology. 14-3-3 Proteins -- physiology. Pancreatic Neoplasms -- pathology.
14-3-3 is down-regulated in certain human cancers, but its expression is increased in pancreatic ductal adenocarcinoma (PDAC). The purpose of the present study was to investigate the potential role of 14-3-3σ in PDAC. The levels of 14-3-3...
Dartmouth Dissertations

The synthetic oleanane triterpenoids and the histone deacetylase inhibitor vorinostat cooperate to delay tumor development in a transgenic model of estrogen receptor-negative breast cancer / by Kim M. Tran.
Electromagnetic fields -- Mathematical models.;""Molecular spectroscopy."";""Nucleotide sequence."";""Macromolecules -- Analysis."";""Electromagnetic induction."";""Unexploded ordnance -- Identification.""
Dartmouth Dissertations

Regulation of CD8+ T cell immunity by retinoic acid / by Yanxia Guo.
Studies have implicated the essential role of Vitamin A (VA) and its active metobolite, retinoic acid (RA) in both host defense and tolerance through manipulation of various immune cells, including T cells, B cells, macrophages and others. CD8⁺ T...
Dartmouth Dissertations

Innate immune responses to HIV-1 and Chlamydia trachomatis in the human female reproductive tract / by Lucy Rudo Mukura.
Female reproductive tract (FRT) secretions contain a spectrum of cytokines, chemokines and antimicrobials that inhibit infection of target cells by HIV-1 and other sexually transmitted pathogens. Innate immune protection maintained by the presence...
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Dartmouth Dissertations

Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
Dartmouth Dissertations

Brain repair after trauma : birth and migration of immature neurons after focal traumatic brain injury in piglets and human children / by Sabrina Rose Taylor.
Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
Dartmouth Dissertations

Characterization of the interaction between Staphylococcus aureus and the cystic fibrosis cell line CFT-1.
Cystic fibrosis -- Immunological aspects. Cystic fibrosis -- Genetic aspects. Staphylococcus aureus infections -- Pathogenesis. Epithelial cells. Lungs -- Pathophysiology.
Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
Dartmouth Dissertations

Evaluation and engineering of Saccharomyces cerevisiae for cellulase expression and growth on insoluble cellulose.
Saccharomyces cerevisiae -- Genetics. Cellulase -- Biotechnology. Cellulose -- Biotechnology. Biomass conversion -- Technological innovations.
Dartmouth Dissertations

Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

Nerve growth factor and the septohippocampal system / by Lan Guo.
Nerve growth factor (NGF), the prototypic neurotrophin, is well characterized for its pro-survival and growth effects in sympathetic and sensory neurons. Acting as a target-derived factor, NGF regulates the maturation of innervating neurons, and...
Dartmouth Dissertations

Computational methods for the discovery and application of protein sequence-structure-function relationships / by Lu He.
Proteins are ubiquitous in cells and are essential to a wide range of biological processes. Since existing proteins occupy only a small portion of the space of possible amino acid composition, understanding their sequence-structure-function...
Dartmouth Dissertations

Small molecule modulation of morphology and metabolism in Candida albicans / by Allia Kaye Smith
Candida albicans is a fungal species that naturally exists as a commensal member of the human microbiota, but can assume a pathogenic lifestyle and subsequently induce life-threatening systemic infections. The ability of the fungus to grow in...
Dartmouth Dissertations

Involvement GP39 and CD40 interactions in the generation of immune responses to allogeneic antigens.
T cells. Antigen presenting cells. CD antigens. Ligands (Biochemistry). Cell interaction. Immune response -- Regulation.
Dartmouth Dissertations

Functional studies of human IgG Fc receptors.
Immunoglobulin G. Immunoglobulins.
Dartmouth Dissertations

Regulation of B lymphocyte proliferation and differentiation through CD40.
B cells. CD antigens. Immune response -- Regulation.
Dartmouth Dissertations

Cif, a novel Pseudomonas aeruginosa toxin.
Pseudomonas aeruginosa infections -- Pathogenesis. Hydrolases. Membrane proteins -- Physiological transport. Genetic regulation. Epoxide Hydrolases -- genetics.
Pseudomonas aeruginosa is the leading cause of morbidity and mortality amongst cystic fibrosis (CF) patients. Following initial colonization of the CF lung by P. aeruginosa , the bacterium establishes chronic, long-term infections. Chronic P....
Dartmouth Dissertations

Dendritic cell Fcγ receptor expression and function
Fc receptors. Dendritic cells. Immune recognition.
Three types of Fc receptors for IgG, FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD 16) are expressed differentially on blood leukocytes. In particular, CD64 and CD32 are constitutively expressed on mononuclear phagocytes of the human myeloid system....
Dartmouth Dissertations

Regulation of neuromuscular signalling: modulation of acetylcholine receptor function.
Neuromuscular transmission. Nicotinic receptors. Muscle contraction -- Regulation. Musculoskeletal system -- Differentiation -- Effect of androgens on.
Dartmouth Dissertations

The transcriptional and post-transcriptional regulation of ecdysterone responsive genes.
Genetic regulation. Ecdysterone. Drosophila -- Genetics.
Dartmouth Dissertations

Computer modeling of total hip replacement : application to joint geometry stress analysis and bone remodeling
Total hip replacement -- Computer simulation.
Dartmouth Dissertations

The role of Estradiol in the regulation of the secretory immune system in the female reproductive tract.
Estradiol. Generative organs Female -- Secretions. Generative organs
Dartmouth Dissertations

Ecdysterone induced genetic reprogramming of cultured Drosophila cell lines.
Ecdysterone. Genetic regulation. Drosophila.
Dartmouth Dissertations

Kinetic characterization of metabolism and antibody production of a hybridoma cell line in high density homogeneous perfusion culture.
Hybridomas -- Metabolism. Hybridomas -- Growth. Cultures (Biology).
Dartmouth Dissertations

Effects of chronic anabolic androgenic steroid exposure on GABAergic neurotransmission and neuronal activity in the mamalian forebrain.
GABA -- Receptors. Anabolic steroids -- Physiological effect. Androgens -- Physiological effect. Prosencephalon. Neurotransmitters -- Effect of drugs on. Psychoneuroendocrinology.
Anabolic androgenic steroids (AAS) are derivatives of testosterone originally designed for therapeutic applications to enhance anabolic potency (protein synthesis and muscle growth) while exerting low androgenic (masculinizing) effects. The...
Dartmouth Dissertations

Bottom-up effects of nutrient enrichment on plants, pollinators, and their interactions.
Meadow ecology -- Colorado. Angiosperms -- Nutrition. Angiosperms -- Pollination. Plants -- Effect of nitrogen on. Insect pollinators -- Ecology -- Colorado. Mountain plants -- Ecology -- Colorado. Bees -- Ecology -- Colorado. Bees -- Nutrition --...
Nutrients play fundamental roles in biological systems, affecting plant growth and quality, community structure, and species interactions. Although the effects of nutrients on primary and secondary production have been well documented, their...
Dartmouth Dissertations

Mechanisms of survival and persistence of Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. ; Pili (Microbiology). ; Proteins -- Secretion. Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of the severe diarrheal disease cholera. Colonization of the host environment by V. cholerae requires the type IV toxin co-regulated pilus (TCP). Adequate colonization by V. cholerae is essential for cholera...
Dartmouth Dissertations

Exploring the role of CD4 T cell help in the generation of CD8+T cell responses against acute and persistent viral infections
T cells -- Receptors. ; Immunologic memory. ; CD8-Positive T-Lymphocytes -- immunology. ; CD4-Positive T-Lymphocytes -- immunology. ; Vaccinia virus -- immunology. ; Herpesviridae Infections -- immunology.
Dartmouth Dissertations

The role of TonB-dependent receptors and alternate sigma factors in the Bradyrhizobium japonicum/soybean symbiosis.
Rhizobium -- Genetics. Cell receptors. Transcription factors. Bacteria.
Bradyrhizobium japonicum forms a nitrogen-fixing symbiosis with soybean. Signaling events, such as production of flavonoids and Nod factor, initiate the interaction, leading to formation of specialized root organs called nodules. A B. japonicum...
Dartmouth Dissertations

Allosteric modulation of GABAa receptors by anabolic-androgenic steroids.
GABA -- Receptors. Allosteric regulation. ; Anabolic steroids -- Physiological effect. ; Androgens -- Physiological effect. ; Receptors
Anabolic-androgenic steroids (AAS) are synthetic derivatives of the gonadal hormone, testosterone. Despite their many untoward side effects, AAS are wildly abused for their ergogenic properties. AAS have numerous effects on many organ systems,...
Dartmouth Dissertations

The differentiation and survival of long-lived plasma cells.
Plasma cells. ; Lymphocyte transformation. ; B cells. Immune response -- Regulation. ; Immunologic Memory -- physiology.
During an immune reaction to an invading pathogen, a population of lymphocytes with receptors that specifically recognize the pathogen are activated and become memory cells. Characteristically, memory lymphocytes persist for long periods of time...
Dartmouth Dissertations

The ecology of Vibrio cholerae: intra- and interspecific interactions.
Vibrio cholerae -- Ecology. Vibrio cholerae -- Growth. Cyanobacteria -- Ecology.
In this dissertation, I present an examination of the role of two biotic interactions in the population dynamics of Vibrio cholerae. Traits with a genetic basis such as size, physiological processes, stress tolerance, and even behavior, are key...
Dartmouth Dissertations

Glucocorticoids and interferons regulate the expression of a novel human mononuclear phagoctye-specific antigen.
Antigens. ; Immune response -- Regulation. ; Glucocorticoids -- Physiological effect.
Dartmouth Dissertations

Regulation of human type I Fc[gamma] receptor by interferon-[gamma] and dexamethasone.
Fc receptors. ; Cellular control mechanisms. ; Interferon. ; Dexamethasone.
Dartmouth Dissertations

Neuronal interferon signaling : implications for HSV-1 replication and pathogenesis / by Pamela Rosato
Herpes simplex virus-1 (HSV-1) establishes lifelong latent infections in the sensory neurons of the trigeminal ganglia (TG) wherein it retains the capacity to reactivate. The interferon (IFN)-driven antiviral response is critical for the control of...
Dartmouth Dissertations

Harnassing natural killer cell receptors for tumor immunotherapy / by Ming-Ru Wu
Despite all the efforts and progress in cancer research, cancer remains a devastating disease. After more than 120 years of research, immunotherapy provides a realistic hope to cure cancer. Several formats of immunotherapy, such as...
Dartmouth Dissertations

microRNA in Porifera : evolution of a molecular mechanism in sponges / by Jeffrey Robinson
Sponges are a historically ambiguous taxon, often considered primitively simple representatives of early Metazoa, living fossils from the era before the complex morphological features of the bilaterian phyla appeared in the Cambrian. Yet recent...
Dartmouth Dissertations

Find results with:

Searching collections:

Add or remove other collections to your search:

Narrow your search by:

Title

Date

Subject

You've searched:

Thumbnail

Title

Subject

Description

Collection

QuickView

Layout options:

		Thumbnail with title
		Grid with smaller thumbnails and more detail

Find results with:

Searching collections:

Add or remove other collections to your search:

Narrow your search by:

Title

Date

Subject

You've searched:

Thumbnail Title Subject Description Collection

QuickView

Layout options:

Thumbnail

Title

Subject

Description

Collection