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- Targeting of the erythroid transcription factor, GATA-1, to specific locations within the human genome.
- Globin genes -- Expression. ; Transcription factors. ; Genetic transcription -- Regulation.
- Dartmouth Dissertations
- Role of GATA-1 in β-globin locus chromatin structure reorganization and eryrhoid [i.e. erythroid] gene expression.
- Chromatin -- Structure. Globin genes -- Expression. Transcription factors. Erythropoiesis. Genetic transcription -- Regulation.
- Despite being cloned over twenty years ago, many regulatory mechanisms of the β-globin genes have yet to be fully elucidated. The regulation of the β-globin locus in erythroid cells requires chromatin structural changes before the genes can be...
- Dartmouth Dissertations
- Pharmacologic induction of human fetal hemoglobin through activation of the NRF2 antioxidant response signaling pathway
- Pharmacologic induction of fetal hemoglobin (HbF) has proven therapeutic potential for ß-hemoglobinopathy patients. Increased HbF reduces disease severity by decreasing sickling in sickle cell disease and reducing α-chain imbalance in...
- Dartmouth Dissertations
- Examining functional variation in oncogene biology : the role of somatic mutations and germline variation on c-Myc and c-Myb / by Scott Andrew Turner.
- The identification and characterization of functional genetic variation is essential for future advances in molecular diagnostics, pharmacogenomics, and personalized medicine. Recent attempts at identifying nucleotide level variation (somatic...
- Dartmouth Dissertations
- The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
- Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
- Dartmouth Dissertations
- Sulfobetaines as novel inhibitors of squalene synthase. A model system for Δ4-3-ketosteroid isomerase.
- Cholesterol -- Synthesis. Enzymes -- Inhibition. Isomerases -- Synthesis.
- This thesis describes the synthesis of sulfobetaines having the general structure $\rm RN\sp{+}(CH\sb3)\sb2(CH\sb2)\sb{x}SO\sb{3\sp{-}}$ as novel inhibitors of squalene synthase. Squalene synthase reductively couples two molecules of farnesyl...
- Dartmouth Dissertations
- A new synthetic route to B-ring derivatives of TMD
- Bicyclic compounds -- Synthesis
- Dartmouth Dissertations
- Investigation of the reactivity of nitrogen substituted oxyallyl cations.
- Nitrogen compounds. Allyl compounds.
- Dartmouth Dissertations
- Cinder cone distribution described using cluster analysis and two-dimensional Fourier analysis in the central Transmexican Volcanic Belt, Mexico, and in SE Guatemala and NW El Salvador.
- Volcanism -- Mexico. ; Volcanism -- Guatemala. ; Volcanism -- El Salvador. ; Cluster analysis.
- Dartmouth Dissertations
- A study of the 13c NMR spectrum of indole
- Indole. ; Nuclear magnetic resonance spectroscopy.
- Dartmouth Dissertations
- The inverse hyperthermia problem and its solution.
- Thermotherapy.
- Dartmouth Dissertations
- CXCR3 and its cognate-chemokine expression : implications for cancer immunotherapy / by Eleanor Clancy-Thompson
- Despite immunogenicity, melanoma-specific vaccines have demonstrated minimal clinical efficacy in patients with established disease, but enhance survival when administered in the adjuvant setting. It has been shown that T cell infiltration of...
- Dartmouth Dissertations
- A proteomics approach to NIMA-related kinase signaling in mitosis / by Sierra N. Cullati
- NIMA-related kinases (Neks) control several aspects of cell division downstream of master mitotic regulators such as Cdk1 and Plk1. Though depletion of Nek6, Nek7, or Nek9 results in cytokinesis failure, to date no molecular mechanism has been...
- Dartmouth Dissertations
- Ultrastructure and histochemistry of the cellular stomach and gastric gland of female Asplanchna sieboldi and of the rudimentary gut of male Asplanchna sieboldi.
- Rotifera.
- Dartmouth Dissertations
- Structure/function analyses of the murine -globin locus through trageted mutations.
- Globin genes -- Expression. Genetic markers. Genetic transcription -- Regulation. Mutation (Biology).
- Genes at the mammalian β-globin loci are arranged in the order of their developmental activation. Expression of individual genes at this locus is controlled by gene proximal and distal cis -regulatory elements. This thesis focused on the function...
- Dartmouth Dissertations
- Ethical problems in predictive DNA based genetic testing created by the artifact of health insurance.
- Human chromosome abnormalities -- Diagnosis -- Moral and ethical aspects. ; Health insurance -- United States. ; Discrimination in insurance -- United States.
- Dartmouth Dissertations
- Chromatin changes associated with the mammalian ß-globin switch.
- Globin genes -- Expression. ; Chromatin. ; Epigenesis. ; DNA -- Methylation. ; Epigenesis.
- Dartmouth Dissertations
- Targeted manipulation of ß-globin promoter chromatin structure: implications for gene therapy of ß-hemoglobinopathies.
- Chromatin. ; Promoters (Genetics). ; Gene targeting. ; Globin genes -- Expression. ; Genetic vectors -- Therapeutic use. ; Hemoglobinopathy -- Treatment. ; Hemoglobinopathy -- Genetic aspects.
- Dartmouth Dissertations
- Inter-specialty differences in outcomes associated with adult primary care physician supply.
- Primary care (Medicine) -- United States -- Evaluation. ; Medicine -- Specialties and specialists. ; Physicians -- Supply and demand -- United States.
- Background. Strengthening the role of primary care is considered a key element in improving the outcomes and efficiency of health care delivery. Previous studies of the benefits of primary care have primarily examined the association of primary...
- Dartmouth Dissertations
- 5-azacytidine induces fetal hemoglobin by a cell signalling mechanism that is upstream of changes in differentiation kinetics and promoter hypomethylation.
- Antineoplastic agents -- Mechanism of action. Hemoglobin -- Synthesis -- Regulation. Protein kinases. Cellular signal transduction. Promoters (Genetics) -- Methylation. Azacitidine -- pharmacology. Fetal Hemoglobin -- biosynthesis. p38...
- The β-hemoglobinopathies sickle cell disease and β-thalassemia represent some of the most common inherited diseases. It is recognized that increased fetal hemoglobin (HbF) ameliorates symptoms, mortality and morbidity in β-hemoglobinopathy...
- Dartmouth Dissertations
- The role of chromatin regulation in gene expression: analyzed through the phenotype characterization of Chd6 ATPase-/- mice and methylation status of the human globin locus.
- Chromatin -- Structure. DNA -- Methylation. Globin genes -- Expression. Adenosine triphosphatase. Proteins -- Chemical modification.
- Epigenetic regulation of gene expression is a developing field of study with many potential therapeutic applications. Chromatin remodeling is necessary for proper mammalian development, and misregulation of this process is associated with many...
- Dartmouth Dissertations
- Temporal regulation of microRNA expression during animal development.
- RNA. Cells -- Growth -- Regulation. Caenorhabditis elegans -- Genetics. Caenorhabditis elegans -- Development. Drosophila melanogaster -- Genetic aspects. Drosophila melanogaster -- Development. Neurons -- Growth. Animal genetics.
- MicroRNAs (miRNAs) are recently discovered family of genes with short non-coding RNA transcripts of 18 to 25 nucleotides in length. lin-4 and let-7 , the founding members of the miRNA gene family, control the timing of developmental programs in the...
- Dartmouth Dissertations
- Inter-specialty differences in outcomes associated with adult primary care physician supply.
- Primary care (Medicine) -- United States -- Evaluation. Medicine -- Specialties and specialists. Physicians -- Supply and demand -- United States.
- Background: Strengthening the role of primary care is considered a key element in improving the outcomes and efficiency of health care delivery. Previous studies of the benefits of primary care have primarily examined the association of primary...
- Dartmouth Dissertations
- Role of rhodopsin endocytosis and NF-kappa B signaling in mediating light-dependent retinal degeneration.
- Retinal degeneration -- Genetic aspects. Photoreceptors -- Molecular aspects. Cell death. Endocytosis. Rhodopsin. NF-kappa B (DNA-binding protein) Cellular signal transduction.
- In humans, progressive loss of vision accompanies many inherited retinal degenerative disorders. In many cases, the affected genes are known. However the molecular pathway of photoreceptor cell death is still elusive. In this thesis, I describe the...
- Dartmouth Dissertations

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