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5-azacytidine induces fetal hemoglobin by a cell signalling mechanism that is upstream of changes in differentiation kinetics and promoter hypomethylation.
Antineoplastic agents -- Mechanism of action. Hemoglobin -- Synthesis -- Regulation. Protein kinases. Cellular signal transduction. Promoters (Genetics) -- Methylation. Azacitidine -- pharmacology. Fetal Hemoglobin -- biosynthesis. p38...
The β-hemoglobinopathies sickle cell disease and β-thalassemia represent some of the most common inherited diseases. It is recognized that increased fetal hemoglobin (HbF) ameliorates symptoms, mortality and morbidity in β-hemoglobinopathy...
Dartmouth Dissertations

The role of the Drosophila SK channel in sensory processing and behavior / by Ahmad Nawwaf Abou Tayoun.
Partially ordered sets. ; Forcing (Model theory). ; Set theory.
Dartmouth Dissertations

Cytoskeletal reorganization in B lymphocyte activation.
Lymphocyte transformation.
Dartmouth Dissertations

Structural, stratigraphic, and thermo-chronological evolution of Trinidad.
Geochronometry -- Trinidad and Tobago -- Trinidad. ; Geology Structural -- Trinidad and Tobago -- Trinidad. ; Geology.
Dartmouth Dissertations

The glucose transporter is a glycoprotein of Mr 55,000 and is probably not phosphorylated in response to biological activators of transport.
Glycoproteins. ; Monoclonal antibodies. ; Immune response.
Dartmouth Dissertations

Rhodopsin-arrestin complex formation as a novel mechanism for light-dependent retinal degeneration.
Visual pigments. ; Cellular signal transduction. ; Rhodopsin. ; G proteins. ; Phosphorylation. ; Photoreceptors. ; Retinal degeneration.
Arrestins are regulatory proteins that participate in the termination of G protein-mediated signal transduction. The major arrestin in the Drosophila visual system, Arrestin 2 (Arr2), has been demonstrated to be essential for the termination of the...
Dartmouth Dissertations

Mechanisms for the regulation of fibrinolysis and cytokine expression by nickel.
Pulmonary fibrosis -- Pathophysiology. ; Fibrinolysis --Genetic aspects. ; Cytokines. ; Immune response -- Regulation. ; Nickel -- Toxicology. ; Lungs -- Dust diseases.
Human epidemiological and animal studies have associated inhalation of nickel dusts with increased incidence of pulmonary fibrosis. The current studies examined the hypothesis that nickel promotes pulmonary fibrosis by inhibiting fibrinolysis and...
Dartmouth Dissertations

Discovering MII1 regulated pathways in hematopoietic stem cells.
Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Dartmouth Dissertations

Development and application of a dual-excitation, digital imaging, fluorescence microscope to investigate parathyroid hormone-stimulated calcium transport in kidney distal tubule cells.
Fluorescence microscopy. ; Calcium -- Physiological transport -- Measurement. ; Renal tubular transport -- Measurement.
Dartmouth Dissertations

Th-dependent B cell activation.
B cells. ; T cells. ; Cell interaction. ; Body fluids -- Immunology.
Dartmouth Dissertations

Effects of selenium deficiency on deiodinase expression and thyroid hormone economy in the rat during development.
Thyroid hormones -- Physiological effect. ; Selenium -- Physiological effect. ; Thyroid hormones -- Synthesis.
The iodothyronine deiodinases, D1, D2, and D3, play a crucial role in determining the circulating and intracellular levels of active and inactive thyroid hormone (TH), and thus have a major effect on TH action during development and adulthood. The...
Dartmouth Dissertations

Isolation of interleukin-2-induced immediate-early genes.
Interleukin-2.
Dartmouth Dissertations

Probing a receptor-binding domain of interleukin-2 by combinatorial cassette mutagenesis.
Interleukin-2. ; Mutagenesis.
Dartmouth Dissertations

The mechanism of action for angiotensin-1-7 in the rostral ventrolateral medulla in the modulation of cardiovascular sympathetic nerve activity / by Mark S. Bilodeau
Elevated sympathetic discharge from the CNS is an underlying pathogenic mechanism in neurogenic hypertension and an exacerbating factor in chronic heart failure (CHF). Current treatment of these diseases focuses on attenuation of the downstream...
Dartmouth Dissertations

Mitochondrial biogenesis in Saccharomyces cerevisiae: transcriptional control by glucose.
Saccharomyces cerevisiae. ; Glucose. ; Mitochondria. ; Gene fusion. ; Cytochromes. ; Mutation (Biology).
Dartmouth Dissertations

Biological and receptor binding properties of interleukin-2 analogs employing site-directed mutagenesis and filamentous phage display.
Interleukin-2 -- Derivatives. ; Ligand binding (Biochemistry). ; Mutagenesis.
Dartmouth Dissertations

Insulin regulation of the glucose transporters in 3T3-L1 adipocytes and BC3H-1 myocytes.
Glucose -- Physiological transport. ; Insulin -- Physiological effect. ; Fat cells. ; Muscle cells.
Dartmouth Dissertations

A novel region in the collagenase promoter is involved in transcriptional activation and repression.
Collagenases. ; DNA-protein interactions.
Dartmouth Dissertations

Study of 3' end RNA processing of herpes simplex virus type 1 thymindine kinase mRNA in vivo and in vitro.
RNA -- Metabolism. ; Herpes simplex virus.
Dartmouth Dissertations

Interleukin-2 analogs with enhanced biological response: a novel ligand based mechanism.
Interleukin-2 -- Derivatives. ; Interleukin-2 -- Receptors. ; Ligand binding (Biochemistry).
Interleukin-2 (IL-2) is an immunoregulatory cytokine whose biological effects are mediated through interaction with specific receptors (IL-2R) on the surface of target cells. Due to its presumed role in generating a normal immune response, IL-2 is...
Dartmouth Dissertations

Biochemical characterization of recombinant acyl coenzyme A:cholesterol acyltransferase expressed in insect Sf9 cell.
Acyltransferases. ; Enzymatic analysis. ; Cholesterol -- Metabolism -- Regulation. ; Cholesterol -- Synthesis -- Regulation. ; Genetic recombination.
Dartmouth Dissertations

Cytokinin and the transcriptional regulation of chloroplast development in Arabidopsis.
Chloroplasts -- Formation. ; Genetic transcription -- Regulation. ; Transcription factors. ; Arabidopsis -- Genetics. ; Arabidopsis proteins. ; Cytokinins.
Cytokinins regulate broad aspects of plant growth and development, such as cell division, root and shoot growth, chloroplast development, and leaf senescence. Cytokinins are perceived by a signal transduction pathway that involves receptors,...
Dartmouth Dissertations

The role of p38 MAP kinase in the regulation of mRNA stability.
Messenger RNA -- Metabolism. ; Mitogens. ; Thalidomide. ; Glucose -- Physiological transport. ; Mitogen-Activated Protein Kinases. ; MAP Kinase Signaling System. ; Protein processings Post-transcriptional. ; Hippel-Lindau Disease.
We have investigated the role of the p38 MAP kinase pathway in regulating gene expression at the level of mRNA stability. The inhibitory effect of thalidomide on Tumor Necrosis Factor (TNF)α production was characterized. Activation of the MAPK...
Dartmouth Dissertations

Controlled signalling systems and convert channels.
Computers -- Access control. ; Data transmission systems. ; Coding theory.
Dartmouth Dissertations

In vitro reconstitution of exocytosis from sea urchin egg plasma membrane and isolated secretory vesicles.
Sea urchins -- Cytology.
Dartmouth Dissertations

The role of p53 in retinoic acid-induced differentiation of human germ cell tumors.
p53 antioncogene -- Regulation. ; Retinoids -- Physiological effect. ; Retinoids -- Receptors. ; Cell differentiation -- Molecular aspects. ; Genetic transcription -- Regulation. ; Germ cells -- Tumors. ; Receptors.
The retinoids exert potent growth and differentiation effects on normal, embryonic and neoplastic cells. Although retinoids are known to regulate gene transcription through activation of retinoid receptors, the direct target genes of retinoid...
Dartmouth Dissertations

Specificity in signaling : bacterial decision-making through the cyclic diguanylate second messenger / by Kurt M. Dahlstrom
Cyclic diguanylate (c-di-GMP) is a primarily bacterial and nearly universal second messenger used to stimulate a variety of responses from the cell by binding effector proteins. It is created by enzymes called diguanylate cyclases (DGCs) and broken...
Dartmouth Dissertations

Biological significance of VIVID photocycle length and the control of gene expression by the Neurospora clock / by Arko Dasgupta
Sensing light from the environment using photoreceptors is of great adaptive significance to eukaryotes. A prominent feature of the photochemistry of these receptors is the photocycle length, the time taken to decay from the initial signaling light...
Dartmouth Dissertations

Expression of sporophytic and gametophytic storage proteins in the quillwort.
Lycopodiaceae -- Spores. ; Club mosses -- Spores. ; Generations Alternating.
Dartmouth Dissertations

Effect of selenium of deficiency of type I 5'-deiodinase.
Selenium -- Physiological effect. ; Enzymes -- Regulation.
Dartmouth Dissertations

An analysis of an ecdysterone response element from the Drosophila hsp27 gene.
Ecdysone. ; Gene expression. ; Drosophila -- Genetics. ; Heat shock proteins.
Dartmouth Dissertations

Differential MCL1 phosphorylation occurs through distinct pathways.
Myeloid leukemia -- Genetic aspects. ; Phosphorylation. ; Antioncogenes. ; Cancer cells -- Growth -- Regulation. ; Immune response -- Regulation.
Protein kinase C activators and microtubule damaging drugs stimulate BCL2 phosphorylation, which has been associated with either enhancement or inhibition of cell viability. In a Burkitt lymphoma cell line, both types of agents likewise stimulated...
Dartmouth Dissertations

Eskimo Shoefly, signalling [signaling] and "the ki...
Eskimo Shoefly, signalling [signaling] and "the kid" (in emulsion: 116 Shoefly signaling and The Kid 50824 [116 May 8, 1914 Eskimo Shoefly (signaling) and the Kid.] Dwelling, tent; Equipment, camera; Individual, male; Wilkins No.116; Original...
Stefansson Collection of Arctic Photographs - Photographic Prints

Molecular, cellular, and physiological characterization of the insulin receptor substrate 4.
Protein-tyrosine kinase. ; Insulin -- Receptors.
Upon activation by binding of insulin, the insulin receptor tyrosine kinase phosphorylates a group of proteins known as the insulin receptor substrates (IRS's). The tyrosine phosphorylated IRS's then act as docking/effector molecules for SH2...
Dartmouth Dissertations

Hedgehog signaling is a critical mediator for urinary bladder cancer.
Bladder -- Cancer -- Molecular aspects. ; Cellular signal transduction. ; Transcription factors -- Pathophysiology. ; Arsenic -- Carcinogenicity. ; Urinary Bladder Neoplasms -- genetics. ; Hedgehog Proteins.
The role of Hedgehog (HH) signaling in bladder cancer is controversial. The HH receptor and negative regulator Patched1 (PTCH1) resides on a region of chromosome 9q, one copy of which is frequently lost in bladder cancer. Inconsistent with PTCH1...
Dartmouth Dissertations

FGF2 in endothelial cell migration, intracellular signalling and receptor endocytosis.
Fibroblast growth factors. Rho GTPases. Cell receptors. Integrins -- Physiological effect. Endocytosis. Vascular endothelium. Cellular signal transduction.
Endothelial cell migration is an important element of a number of biological processes, including angiogenesis. The fibroblast growth factors (FGFs) are a family of angiogenic heparan-binding proteins that potently induce endothelial migration....
Dartmouth Dissertations

Light and circadian regulation in Neurospora crassa.
Neurospora crassa -- Effect of light on. ; Neurospora crassa -- Genetics. ; Circadian rhythms. ; Genetic transcription -- Regulation. ; Cryptochrome. ; Phytochrome.
Dartmouth Dissertations

Characterization of catalase in Arabidopsis thaliana.
Arabidopsis thaliana -- Genetics.
The Arabidopsis catalase gene family contains at least three genes, encoding subunits which combine in tetramers to form 7 detectable isozymes. Two of these genes are within 250 bp of each other at a single locus (CAT3/1) near the top of chromosome...
Dartmouth Dissertations

Transgenic cyclin E murine models as discovery tools for lung cancer biology, therapy, and prevention.
Lungs -- Cancer -- Genetic aspects. ; Cyclins -- Pathophysiology. ; Transgenic mice. ; Pharmacogenomics. ; Cyclin E -- genetics.
Dartmouth Dissertations

Bcl-2 family proteins and the regulation of apoptosis.
Apoptosis. ; Proteins. ; Cellular signal transduction. ; Proto-Oncogene Proteins c-bcl-2.
Apoptosis is induced by chemicals and death receptor activation. Although the stimuli are different, common proteins are activated downstream. The Bcl-2 family of proteins plays an important role in mediating apoptotic signaling at the mitochondria...
Dartmouth Dissertations

Identification and role of protein-protein interactions in signaling by the ethylene receptors of Arabidopsis.
Protein-protein interactions. ; Ethylene -- Receptors. ; Cellular signal transduction. ; Arabidopsis -- Genetics.
There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis. In this study, I tested the hypothesis that ethylene receptors mediate ethylene signaling through protein-protein interactions. First, I demonstrated that ethylene...
Dartmouth Dissertations

Functional analysis of cell cycle genes by genome-wide expression data and meta-analysis of RNAi screens.
Cell cycle -- Regulation. ; Genetic regulation. ; Small interfering RNA. ; Spindle (Cell division). ; Epithelial cells -- Genetic aspects. ; Mammary glands -- Cytology. ; Cell lines. ; Cell Cycle -- genetics. ; Genes cdc. ; RNA Interference. ;...
Successful traversal of the cell division cycle is paramount for maintaining a cell's genomic integrity and fitness. To ensure the faithful replication and segregation of the genome, cellular components, and cytoplasm, eukaryotes have evolved a...
Dartmouth Dissertations

Cytotoxic trigger molecules on human myeloid cells.
Cell-mediated cytotoxicity.
Dartmouth Dissertations

The regulation of AMP-activated protein kinase (AMPK) in an insulinoma cell line, adipocytes and muscle.
Protein kinases. ; Adenylic acid. ; Islands of Langerhans -- Tumors. ; Fat cells. ; Muscle cells. ; Adenoviruses.
Dartmouth Dissertations

A versatile approach to ellipticine and its analogues: Preparation and free radical reactions of 2-bromo-3-substituted indoles.
Alkaloids -- Synthesis. ; Heterocyclic compounds -- Synthesis. ; Indole.
Dartmouth Dissertations

SGK1 is an important determinant of sodium channel activity in the mammalian collecting duct.
Aldosterone -- Mechanism of action. ; Aldosterone -- Physiological effect. ; Adrenocortical hormones -- Genetic aspects. ; Sodium channels -- Genetic aspects. ; Genetic regulation.
Hypertensive disorders, as well as congestive heart disease. Despite extensive research on the regulatory events that occur between aldosterone induced transcription and the early activation of epithelial sodium channels (ENaC ) in cortical...
Dartmouth Dissertations

Control of developmental timing in Caenorhabditis elegans by lin-14.
Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Growth. ; Cellular control mechanisms. ; Heterochrony (Biology). ; Developmental genetics.
The heterochronic gene lin-14 affects certain somatic cell-fate choices during post-embryonic development in C. elegans. In lin-14 mutants, cells express stage-specific developmental programs, such as cell divisions or dauer entry, at inappropriate...
Dartmouth Dissertations

A role for TP63 in breast cancer initiation.
Despite the availability of targeted therapies, breast cancer metastasis and recurrence remain clinically challenging problems. Understanding the function of stem cells in this disease may lead to identification of genetic pathways underlying...
Dartmouth Dissertations

Effects of mitomycin C and other DNA crosslinking agents on gene expression: modulation of cancer cell multidrug resistance in cell culture and in vivo.
Mitomycin C -- Genetic aspects. ; DNA damage. ; Drug resistance in cancer cells. ; Cancer -- Chemotherapy -- Genetic aspects.
Our laboratory is concerned whether the distribution of chemically-induced DNA damage is non-random at the level of individual genes. Using changes in gene expression as a marker for DNA damage, we have previously demonstrated that genotoxic...
Dartmouth Dissertations

Cell cycle characteristics of a microtubule-associated protein that is a component of the mitotic apparatus.
Phosphoproteins. ; Microtubules. ; Mitosis. ; Tubulins.
Dartmouth Dissertations

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