Microwave spectroscopy. Imaging systems -- Design and construction. Diagnostic imaging -- Digital techniques. Breast -- Cancer -- Diagnosis. Microwave imaging in medicine.
Microwave spectroscopy has been investigated as a possible modality for breast imaging because of the significant contrast in electrical properties between normal and malignant tissue over the microwave spectrum. A liquid-coupled, non-contacting...
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Circadian rhythms in a wide variety of cellular and metabolic processes are well documented in many organisms. An important step in understanding the molecular basis of the circadian clock is the characterization of clock-controlled genes. mRNA...
Our conscious experience of memory often includes reconstuctions of the past in order to fill the gaps of forgotten events and details. The goal of this thesis is to use the tools of cognitive neuroscience to better understand the cognitive and...
For the most part, research on self-regulation has focused on behavior-control, which is how people self-regulate in the face of immediate urges and temptations (e.g., resisting cookies that are close at hand, or resisting beer that is being freely...
Thermodynamics, and the classic balance between entropy and enthalpy, provides a proverbial zoo of exotic phase behaviour that chemists can harness to create new materials out of simple liquids and polymers. The diversity of self-assembling...
This project focuses on the development of research tools and methods that are used to study the relationship between neural activity and subsequent hemodynamic responses in the human brain. This relationship, referred to as neurovascular coupling,...
Opinion dynamics is a complex procedure that entails a cognitive process when it deals with how a person integrates influential opinions to form revised opinion. Early research on opinion formation and social influence can be traced back to the...
Digital integrated circuits -- Testing. Digital integrated circuits -- Testing -- Mathematical models. Digital integrated circuits -- Design and construction.
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated) systems have been characterized as adaptive immune systems in bacteria and archaea, providing defense against mobile genetic elements, including bacteriophage,...
Drosophila. Photoreceptors. TRP channels. Cellular signal transduction.
The phototransduction cascade in Drosophila is a prototypical G-protein signaling pathway and many of its components have been well-studied. Early genetic screens identified many of the major proteins involved in this pathway and study over the...
This work studied the effects of silt-sized particles on the mechanical properties and microstructures of laboratory-grown granular ice from -20°C to -2°C. Experimental findings show that such particles significantly affect the...
Structural control (Engineering). ; Smart structures -- Vibration. ; Strains and stresses -- Computer simulation. ; Automatic control -- Sensitivity. ; Feedback control systems.
This thesis investigates vibration-based damage identification problems in smart structures. Vibration-based damage metrics suffer from small sensitivity of modal properties to damage, thus making it difficult to detect, locate, and determine the...
Nuclear magnetic resonance spectroscopy -- Data processing. ; Proteins -- Analysis -- Mathematical models. ; Computer algorithms.
Our aim is to enhance high-throughput applications of Nuclear Magnetic Resonance (NMR) through the development of efficient computational methods that operate on sparse (minimal) sets of experimental NMR data. We have developed a family of four...
Problem Statement Patient safety in the modern hospital is supported by multiple human and technological systems, and this type of high-risk/high-complexity domain requires multiple layers of protection against harm. This fault-tolerant approach is...
CD antigens. Immune response -- Regulation. Hemoglobin.
CD163 is a monocyte- and macrophage-specific surface glycoprotein proposed to function in the maintenance of homeostasis and the resolution of inflammation. CD163 binds hemoglobin-haptoglobin complexes implicating this receptor as a hemoglobin...
Little is known about the emergence of life from nonliving precursors. A key missing- piece is the origin of homochirality: nearly all life is characterized by exclusively dextrorotary sugars and levorotary amino acids. The research presented in...
Spindle (Cell division)
Microtubules.
Kinesin.
Medical Term Molecular Motor Proteins.
Microtubule-Associated Proteins.
A pre-requisite for proper health of the cell and the organism is accurate chromosome segregation during cell division. Defects in chromosome segregation lead to aneuploidy, a hallmark of an unstable genome and a frequent attribute of cancer and...
Spatial localization of sound depends on interaural time delay (ITD), level difference, and on the interaction of the source with the head, torso, and pinna. Head-related transfer functions (HRTFs) model the dynamics that are used by listeners to...
Neural stem cells (NSCs) have the capacity to proliferate and give rise to multiple major central nervous system cell types and represent a possible cell of origin in gliomagenesis. Deletion of the tumor suppressor gene Tp53 (p53) results in...
Alzheimer's Disease (AD) is a devastating neurodegenerative disease its pathogenesis is linked with cholesterol metabolism. Acyl-CoA:cholesterol acyltransferases (ACATs) are key enzymes involved in cholesterol homeostasis that catalyze the...