Magnetic susceptibility imaging of magnetic nanoparticles (mNPs) has many potential applications in biomedicine such as contrast enhanced imaging and image guidance for magnetic hyperthermia therapy. This thesis describes three imaging methods...
Optical spectroscopy. Magnetic resonance imaging. Breast -- Cancer -- Imaging.
Magnetic Resonance (MR)-guided Diffuse Optical Imaging is an emerging technique to improve breast cancer imaging. This modality combines the high sensitivity of breast MR with images of tissue physiology, including blood content, oxygen saturation,...
Casimir effect. Zero-point field. Electric conductivity. Quantum electrodynamics.
The Casimir force arises from an alteration of boundary condition in vacuum and is often regarded as a manifestation of quantum zero point energy. Considerable progress has been made in the last decade with an impressive achievement of experimental...
Many alkaloids of biological importance have the 11H-pyrido (4,3,2-mn) acridine ring structure such as cystodytin and amphimedine. It would be desirable to find an effective way to synthesize a wide variety of these compounds using a single...
Nitric oxide -- Analysis. ; Dithiocarbamates. ; Iron compounds. ; Organonitrogen compounds. ; Electron paramagnetic resonance spectroscopy.
Nitric oxide is synthesized by living organisms and plays important roles in circulatory, neurological, and immune function. Nitric oxide can also play pathophysiological roles, depending on the amount of the molecule, the presence of other species...
The furanosteroids are a special class of natural products that feature a furan ring fused to the steroid nucleus at C-4 and C-6. In 1945, viridin, the parent member of this group, was isolated by Grove and coworkers from the fungas Gliocladium...
Chapter One. Synthesis and Structure of Chiral Pt(Duphos) Terminal Phosphido Complexes. Treatment of Pt halide precursors with a secondary phosphine in the presence of the base NaOSiMe 3 gave the terminal phosphido complexes Pt(Duphos)(Ph)(PMeIs)....
Introduction. This chapter provides a brief overview of the thesis. Chapter 1: tert-butyl-diphosphabutarene - Synthesis and reactivity of a novel phosphacycle. Treatment of 1,2-bis(dichlorophosphino)benzene (12) with tert-butylmagesium chloride...
Two localized spectroscopic imaging methods were investigated to detect and discriminate microscopic pathologies at the surface of excised breast tissues in order to improve resection completeness during breast conserving surgery. A scanning in...
Chapter One: Synthesis of aryl-based cyclopentadienyl lithium compounds for self-assembly. Cyclopentadienyl (Cp) lithium derivatives are known to form [eta]⁵-coordinated, electrostatically bonded, polymeric supersandwich structures in the solid...
Strong evidence exists showing that stellar evolution models are unable to accurately predict the fundamental properties of low-mass stars. Observations of low-mass stars in detached eclipsing binaries (DEBs) indicate that stellar models...
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Molecular optical imaging in vivo has potential for functional assessment of tumor tissue at the cellular and subcellular level. Advances in biological understanding of genomics and proteomics have increased the knowledge of possible cellular...
This thesis presents data from ground camera observations of the aurora conducted from Alaska during the winters of 2005 through 2007. In conjunction with these camera observations, conjugate radar observations of the auroral ionosphere were...
After decades of searching we have yet to find the progenitor systems for type Ia supernovae. In fact most of what we know about this homogeneous class of supernovae is from spectral features associated with the incinerated remains of the C+O white...
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Annual screening mammograms are recommended for all women above 40 years of age for early detection of breast cancer, and are known to improve cancer mortality rates. However, mammography is hampered by low sensitivity and a high rate of false...
This project focuses on the development of research tools and methods that are used to study the relationship between neural activity and subsequent hemodynamic responses in the human brain. This relationship, referred to as neurovascular coupling,...
Diffuse optical imaging techniques can be combined with standard imaging technologies such as computed tomography (CT) and magnetic resonance (MR) imaging to allow measurement of spectroscopic signals pertaining to the molecular components of...
Metal ions confer structural stability and reactivity to a large number of proteins that use the amino acids histidine (His) and cysteine (Cys) to form stable metal-ligand complexes. The stability of metal-His and metal-Cys interactions and their...
Molecular imaging of cancer features is a critical part of advancing better tools for oncology management and drug discovery, yet it is still evolving as a useful tool. Diffuse Fluorescence Tomography (FT) is one approach to molecular imaging, used...
Chemical sensing and separation is a constant challenge intriguing many scientists. Through numerous efforts, revolutionary techniques and innovative materials have been successfully developed to solve this old problem. However, a practical but...
The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
Cataclysmic variable stars (CVs) are close, interacting binary systems comprised of a white dwarf and a companion star, which is typically a late-type dwarf star. Their progenitor systems are post common envelope binaries (PCEBs) with a white dwarf...
Quantum wires and dots can be created by patterning inhomogeneous strain on semiconductor quantum wells. I have used laser spectroscopic methods to study the carrier transfer from the host quantum well to quantum wires and dots. For quantum dot...
Magneto-spectroscopy is used to characterize the confinement properties of strain-induced quantum wires and dots. The wires and dots are low energy regions in an ordinary GaAs/AlGaAs quantum well that are formed when microscopic...