Dartmouth Digital Library Program

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Role of cytochrome P4503A in acetaminophen toxicity.
Acetaminophen -- Toxicology. ; Hepatotoxicology. ; Cytochrome P-450 -- Pathophysiology. ; Rats -- Physiology.
CYP3A has the highest affinity for oxidation of Acetaminophen (APAP) with a Km close to the concentration observed in human serum after administration of therapeutic doses of APAP. CYP3A may be induced by numerous drugs as well as alcohols. We...
Dartmouth Dissertations

Acquisition and registration of 3D optical surface scanning, MRI, and microwave tomographic imaging for improved clinical breast imaging and surgical planning / by Matthew John Pallone.
Continual improvements to clinical breast imaging technologies have led to ever earlier detections and increasingly accurate localizations of female breast cancers. While these advancements have certainly improved the prognoses of many patients,...
Dartmouth Dissertations

Brain repair after trauma : birth and migration of immature neurons after focal traumatic brain injury in piglets and human children / by Sabrina Rose Taylor.
Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
Dartmouth Dissertations

Characterization of the interaction between Staphylococcus aureus and the cystic fibrosis cell line CFT-1.
Cystic fibrosis -- Immunological aspects. Cystic fibrosis -- Genetic aspects. Staphylococcus aureus infections -- Pathogenesis. Epithelial cells. Lungs -- Pathophysiology.
Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
Dartmouth Dissertations

C.O.A.L.1: a dynamic model for the analysis of United States energy policy.
Energy policy -- United States -- Mathematical models.
Dartmouth Dissertations

Performance decrement following insolvable problems: learned helplessness or failure anxiety?
Failure (Psychology);Helplessness (Psychology)
Dartmouth Dissertations

Sex-specific interactions of anabolic androgenic steroids with voluntary exercise and chronic alcohol consumption on anxiety-like behaviors in mice (Mus musculus) / by Marie Morenike Onakomaiya.
The overarching goal of this thesis was two-fold. First, to determine if the effects of chronic anabolic androgenic steroid (AAS) treatment on anxiety-like behaviors are sex-specific and second to determine how different environmental modulators...
Dartmouth Dissertations

The role of gut commensals in regulating susceptibility to acute liver damage / by Stela Celaj.
Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
Dartmouth Dissertations

Exercise and the brain : impacts on cognition neural function and mental health / by Andrea M. Robinson.
It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
Dartmouth Dissertations

Modulation of swarming motility in Pseudomonas aeruginosa / by Dae Gon Ha.
Swarming motility is a flagella-dependent surface motility, and is also a form of bacterial group behavior. Similar to its counterpart biofilm formation, our understanding of swarming motility has been hampered by its complex set of requirements...
Dartmouth Dissertations

Fractal models in the visual perception of textures and surfaces in nature.
Visual perception. Fractals. Computer graphics. Uniformity of nature -- Mathematical models.
Dartmouth Dissertations

Cif, a novel Pseudomonas aeruginosa toxin.
Pseudomonas aeruginosa infections -- Pathogenesis. Hydrolases. Membrane proteins -- Physiological transport. Genetic regulation. Epoxide Hydrolases -- genetics.
Pseudomonas aeruginosa is the leading cause of morbidity and mortality amongst cystic fibrosis (CF) patients. Following initial colonization of the CF lung by P. aeruginosa , the bacterium establishes chronic, long-term infections. Chronic P....
Dartmouth Dissertations

The effects of size dichopticity on the perception of depth.
Depth perception.
Dartmouth Dissertations

Effects of chronic anabolic androgenic steroid exposure on GABAergic neurotransmission and neuronal activity in the mamalian forebrain.
GABA -- Receptors. Anabolic steroids -- Physiological effect. Androgens -- Physiological effect. Prosencephalon. Neurotransmitters -- Effect of drugs on. Psychoneuroendocrinology.
Anabolic androgenic steroids (AAS) are derivatives of testosterone originally designed for therapeutic applications to enhance anabolic potency (protein synthesis and muscle growth) while exerting low androgenic (masculinizing) effects. The...
Dartmouth Dissertations

The effects of endocrine disruptors on the development of Xenopus embryos.
Xenopus laevis -- Embryology. Xenopus laevis -- Endocrinology. ; Estrogen -- Physiological effect. ; Estrogen -- Toxicology. ; Nonylphenol -- Physiological effect. Endocrine toxicology.
Many environmental toxicants found in pesticides, herbicides, and industrial solvents are believed to have deleterious effects on development by disrupting hormone-sensitive processes. Xenopus embryos were exposed to commonly encountered endocrine...
Dartmouth Dissertations

Teaching diverse orthopaedic patient populations about deliberative decision making skills : testing a design strategy for online patients' decision aids
Clinical medicine -- Decision making. ; Medical informatics. ; Patient participation. ; Osteoarthritis -- Treatment. ; Knee -- Diseases -- Treatment. ; Decision Making. ; Decision Support Techniques.
Problem Statement. Effective patients' decision aids (PtDAs) help patients understand clinical information and reduce decisional conflict. PtDAs that also explicitly provide guidance through four """"Deliberative Steps"""" may achieve additional...
Dartmouth Dissertations

The role of decision strategies in the development of visual information processing
Visual perception. ; Child psychology.
Dartmouth Dissertations

Characterization of the interaction of the chemotherapeutic drug mitomycin C with DNA in vitro and in vivo and effects on specific DNA-protein interactions.
Mitomycin C -- Mechanism of action. ; DNA -- Effect of mitomycin C on. ; Genetic expression -- Effect of mitomycin C on. ; DNA-protein interactions -- Effect of mitomycin C on.
Mitomycin C (MMC) is a chemotherapeutic drug that reacts with the N$\sp2$ of guanine to form monoadducts, interstrand and intrastrand crosslinks. These lesions, especially the interstrand crosslink, are believed to be responsible for the potent...
Dartmouth Dissertations

Circadian and non-circadian oscillators in Neurospora crassa.
Circadian rhythms. Neurospora crassa -- Genetics. Genetic transcription -- Regulation. Choline. Temperature. Circadian Rhythm -- genetics. Choline Deficiency -- genetics.
The circadian clock of the filamentous fungus, Neurospora crassa, consists of a frequency-white-collar ( frq-wc ) based and transcription-translation-derived oscillator. Negative feedback regulation is essential for the oscillatory process, in...
Dartmouth Dissertations

Emergent coherent structures in nonequilibrium field theory.
Coherent states. Quantum field theory. Nonlinear theories.
In this thesis we study the properties of time-dependent, nontopological configurations and their effect on the macroscopic properties of a system described by a nonlinear field theory. These structures seem to be ubiquitous in relativistic field...
Dartmouth Dissertations

Harnassing natural killer cell receptors for tumor immunotherapy / by Ming-Ru Wu
Despite all the efforts and progress in cancer research, cancer remains a devastating disease. After more than 120 years of research, immunotherapy provides a realistic hope to cure cancer. Several formats of immunotherapy, such as...
Dartmouth Dissertations

Eisosomes organize the plasma membrane of yeast / by Ruth V. Kabeche
The cortical cytoskeleton mediates a range of cellular activities such as endocytosis, cell motility, and the maintenance of cell rigidity. In yeast cells, prominent cortical structures called eisosomes generate specialized domains termed MCCs to...
Dartmouth Dissertations

Investigation of ER-Golgi membrane proteins influencing COPII tethering and fusion / by Indrani Mukherjee
Protein secretion is executed by the secretory pathway, which involves the delivery of membrane and soluble secretory proteins in vesicle intermediates that capture newly-synthesized proteins assembled in the endoplasmic reticulum (ER) and then...
Dartmouth Dissertations

Context dependency of plant-plant and human-plant interactions in alpine and arctic tundra / by Simone S. Whitecloud
While plant-plant interactions define community patterns in alpine tundra around the world, topography and elevation and the resulting physical changes that occur when moving down-slope play a greater role in community formation and maintenance in...
Dartmouth Dissertations

Interactions between the carcinogen chromium(VI) and DNA.
DNA. ; Chromium. ; Thiols.
Dartmouth Dissertations

The cloning and characterization of genes involved in amino acid metabolism in Neurospora crassa.
Neurospora crassa -- Genetics. ; Molecular cloning.
Dartmouth Dissertations

Residential indoor and outdoor air pollution.
Air -- Pollution. ; Indoor air pollution. ; Air -- Pollution -- Measurement.
The polycyclic aromatic hydrocarbon (PAH) content of ambient air at several locations is described. The indoor sites examined included those having woodstoves, fireplaces, and kerosene heaters as supplements to oil heat, as well as one test home...
Dartmouth Dissertations

Cellulose hydrolysis and fermentation by Clostridium thermocellum for the production of ethanol.
Clostridium -- Biotechnology. ; Cellulose. ; Hydrolysis. ; Fermentation. ; Alcohol -- Synthesis.
Dartmouth Dissertations

Molecular characterization of three ZIP metal transporters in Arabidopsis thaliana.
Arabidopsis thaliana -- Physiology. Zinc -- Physiological transport. Iron -- Physiological transport. Homeostasis. Trace elements in plant nutrition.
Iron and zinc are essential metal micronutrients that most humans acquire from plant-based diets. Unfortunately, plants are not a good source of these micronutrients, so billions of people worldwide suffer from deficiencies of these two elements....
Dartmouth Dissertations

The role of core binding factor in the pathogenesis of the Moloney murine leukemia virus.
Retroviruses -- Pathogenesis. ; Virus diseases -- Pathogenesis. ; Genetic transcription -- Regulation. ; Viral genetics. ; Mouse leukemia viruses.
Dartmouth Dissertations

Actions of substances placed in the cat cerebrospinal fluid space.
Pharmacology, Experimental. ; Cats.
Dartmouth Dissertations

An investigation of the physiology of a filamentous 'iron bacterium' : iron deposition in the genus Sphaerotilus.
Bacteria -- Morphology; Iron bacteria; Sphaerotili.
Dartmouth Dissertations

The effect of estradiol-17ß and insulin on protein synthesis in primary monocultures of amphibian hepatocytes.
Proteins -- Synthesis. ; Insulin. ; Hormones. ; Amphibians.
Dartmouth Dissertations

An examination of Raf-1 expression and kinase activity throughout the T lymphocyte cell cycle.
Proto-oncogenes. ; T cells. ; Phosphotransferases.
Dartmouth Dissertations

Effects of selenium deficiency on deiodinase expression and thyroid hormone economy in the rat during development.
Thyroid hormones -- Physiological effect. ; Selenium -- Physiological effect. ; Thyroid hormones -- Synthesis.
The iodothyronine deiodinases, D1, D2, and D3, play a crucial role in determining the circulating and intracellular levels of active and inactive thyroid hormone (TH), and thus have a major effect on TH action during development and adulthood. The...
Dartmouth Dissertations

Characterization of COPII vesicle proteins involved in sorting between the endoplasmic reticulum and golgi apparatus in Sacch[a]romyces cerevisiae.
Membrane proteins -- Physiological transport. ; Carrier proteins. ; Biological transport -- Regulation. ; Saccharomyces cerevisiae -- Cytology. ; Golgi apparatus. ; Endoplasmic reticulum.
Intracellular transport between the ER and Golgi is mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. Bi-directional vesicle transport maintains distinct organelle composition through a process known as...
Dartmouth Dissertations

Investigation of Yip1p function in transport between the ER and the Golgi complex.
Membrane proteins -- Physiological transport. Carrier proteins. Biological transport -- Regulation. Saccharomyces cerevisiae -- Physiology. Saccharomyces cerevisiae -- Genetics. Endoplasmic reticulum. Golgi apparatus.
The eukaryotic secretory pathway delivers proteins and lipids to their correct destination in a regulated manner. Transport through the secretory pathway is mediated by vesicles or tubular elements that bud from donor compartments. These transport...
Dartmouth Dissertations

Cytokinin and the transcriptional regulation of chloroplast development in Arabidopsis.
Chloroplasts -- Formation. ; Genetic transcription -- Regulation. ; Transcription factors. ; Arabidopsis -- Genetics. ; Arabidopsis proteins. ; Cytokinins.
Cytokinins regulate broad aspects of plant growth and development, such as cell division, root and shoot growth, chloroplast development, and leaf senescence. Cytokinins are perceived by a signal transduction pathway that involves receptors,...
Dartmouth Dissertations

Investigation of vesicle fusion in ER to Golgi transport.
Membrane proteins -- Physiological transport. ; Biological transport -- Regulation. ; Cell membranes. ; Golgi apparatus. ; Endoplasmic reticulum. ; Saccharomyces cerevisiae -- Cytology.
Many intracellular transport events are mediated by vesicles that bud from donor membranes and then fuse with acceptor membranes. The transport of secretory proteins between the ER and Golgi compartments of the yeast Saccharomyces cerevisiae has...
Dartmouth Dissertations

Investigation of Sec22p in ER to Golgi transport in Saccharomyces cerevisiae.
Membrane proteins -- Physiological transport. Membrane fusion. Biological transport -- Regulation. Cell membranes. Saccharomyces cerevisiae -- Cytology. Golgi apparatus. Endoplasmic reticulum.
Vesicle mediated intracellular transport through the secretory pathway requires the formation of transport vesicles from a donor compartment followed by vesicle tethering and fusion with an appropriate acceptor compartment. The anterograde...
Dartmouth Dissertations

Isolation and characterization of two distinct mutations affecting cholesteryl ester synthesis in mammalian cells.
Cholesterol. ; Esters. ; Mammals -- Cytology. ; Cell metabolism.
Dartmouth Dissertations

Dynamic model of the United States electric utility industry, 1950-2010.
Electric utilities -- United States -- Mathematical models.
Dartmouth Dissertations

Enhanced attribution for networked copyright management.
Copyright and electronic data processing. ; Copyright -- Computer programs. ; Multimedia systems. ; Wide area networks (Computer networks). ; Object-oriented methods (Computer science)
Dartmouth Dissertations

Metal distribution in Arabidopsis.
Arabidopsis -- Effect of metals on. ; Zinc -- Physiological transport. ; Iron -- Physiological transport. ; Plants -- Effect of iron on. ; Plants -- Effect of zinc on.
Iron and zinc deficiency commonly limit plant growth and crop yields. Furthermore, deficiencies in both of these micronutrients are common throughout the world, particularly in developing countries where people may only consume simple diets...
Dartmouth Dissertations

Somatic cell and molecular genetic analysis of various Chinese hamster ovary (CHO) mutant cells defective in sterol-dependent regularion of cholesterol biosynthesis and LDL receptor expression.
Molecular cloning. ; Genetic regulation. ; Somatic cells. ; Sterols. ; Cholesterol -- Metabolism.
Dartmouth Dissertations

SGK1 is an important determinant of sodium channel activity in the mammalian collecting duct.
Aldosterone -- Mechanism of action. ; Aldosterone -- Physiological effect. ; Adrenocortical hormones -- Genetic aspects. ; Sodium channels -- Genetic aspects. ; Genetic regulation.
Hypertensive disorders, as well as congestive heart disease. Despite extensive research on the regulatory events that occur between aldosterone induced transcription and the early activation of epithelial sodium channels (ENaC ) in cortical...
Dartmouth Dissertations