NAD (Coenzyme) -- Metabolism. Nicotinamide -- Mechanism of action. Genetic regulation. Nicotinamide-beta-riboside.
NAD+ is an essential co-enzyme for hydride transfer enzymes and a consumed substrate of multiple signaling enzymes including the sirtuins, a family of protein lysine deacetylases shown to regulate longevity in a wide array of organisms. We have...
This research attempts to combine known methodology with new chemistry towards the preparation of extended polycyclic aromatic hydrocarbons (PAH). The generation and Diels-Alder trapping of 1,7- and 2,6-naphthalene bisarynes was attempted for the...
A novel synthetic route to the synthesis of 9-propyl-10-azacyclododecan-12-olide (1), a natural allomone isolated from the Mexican bean beetle pupa, is presented. The salient features of this synthetic route are a regioselective Beckmann...
Little is known about the emergence of life from nonliving precursors. A key missing- piece is the origin of homochirality: nearly all life is characterized by exclusively dextrorotary sugars and levorotary amino acids. The research presented in...
Purple sulfur bacteria (PSB) can dominate the nitrogen, carbon, and sulfur cycles in anoxic ecosystems via their anoxygenic photosynthetic metabolisms and are the only producers of the carotenoid, okenone, a biomarker targeted for photic zone...
Chapter 1: The dimethylation of the C2-symmetric Pt-phosphido complex Pt((R,R)-Me-DuPhos)(IsPCH2PIs) (Is = 2,4,6-(iPr)3C6H2) to yield rac- and meso- [Pt((R,R)-Me-DuPhos)(IsMePCH2PMeIs)][OTf]2 represents an interesting case of the Horeau principle...
The reversible elimination reactions of beta acyloxyketone 1 and beta alkoxyketone 2 were studied by monitering formation of the product enones in the UV spectra, and, in the case of 2, by using ('13)C NMR to follow deuterium incorporation into the...
Regulation of transepithelial sodium transport by corticosteroids occurs in two phases: early and delayed. The early phase involves the activation and translocation of pre-existing epithelial sodium channels (ENaC); whereas, the delayed phase...
Retinitis Pigmentosa is an inherited retinal degenerative disorder, initiated by point mutations on the rhodopsin gene. This thesis set forth to understand the mechanism of this pathogenesis, as well as to further improve our understanding of...
Chapter one: Synthesis, resolution and application of P-chirogenic phosphines. This chapter serves as a general introduction, and gives a brief overview of the synthesis, resolution and applications of chiral organophosphorus compounds. In...
Infections by pathogenenic microbes are an increasing problem due to a lack of universal vaccines and growing resistance to current antibiotics. The constant battle for researchers in the fight against pathogens is to design new and improved drugs...
The furanosteroids are a special class of natural products that feature a furan ring fused to the steroid nucleus at C-4 and C-6. In 1945, viridin, the parent member of this group, was isolated by Grove and coworkers from the fungas Gliocladium...
The chemistry of indole can be reversed and redirected by the addition of powerful electron-withdrawing groups. Incorporation of a nitro group at C-2 or C-3 renders the adjacent carbon susceptible to nucleophilic attack. Nitro, cyano, and...
Tetrapyrroles -- Synthesis. Tetrapyrroles -- Mechanism of action. Transition metal catalysts.
Previous studies have shown that the mucosal immune system is present in the female reproductive tract and under hormonal control. With the recognition that underlying stromal cells regulate epithelial cell function and hormonal responsiveness,...
I. Intermolecular C-S Bond Forming Reactions
The relatively small number of efficient C-S bond forming reactions in the literature prompted an investigation into the synthesis of allylic thioethers. The technology that we developed allowed us, in...
Introduction. This chapter provides a brief overview of the thesis. Chapter 1: tert-butyl-diphosphabutarene - Synthesis and reactivity of a novel phosphacycle. Treatment of 1,2-bis(dichlorophosphino)benzene (12) with tert-butylmagesium chloride...
Free radicals (Chemistry). ; Electron donor-acceptor complexes. ; Ions.
In this study, the initial charge separation distance and its impact on free radical ion (FRI) formation are investigated in detail. Transient photocurrent techniques together with other spectroscopic methods were used with a series of donors and...
NAD (Coenzyme) -- Metabolism.
Nicotinamide -- Mechanism of action.
Phosphatases.
Phosphates -- Metabolism -- Regulation.
Medical Term Nucleotidases -- metabolism.
Nicotinamide-beta-riboside.
Nicotinamide adenine dinucleotide (NAD+) is classically known as an essential co-enzyme for hydride transfer reactions in metabolism. More recently, it has been recognized as a consumed substrate of ADPribose transfer enzymes...
The furanosteroid class of compounds issues a siren call to both chemists and biologists alike -- the intriguing pentacyclic skeleton, densely packed and highly functionalized, continues to entice synthetic minds to develop new and elegant methods...
Abstract (Summary) Chapter One. Platinum-Catalyzed Asymmetric Alkylation of Bis(secondary) Phosphines. Efficient Screening and the Synthesis of an Enantiomerically Pure C 2 -Symmetric Diphosphine . Platinum-catalyzed asymmetric alkylation of...
Chapter One: Synthesis of aryl-based cyclopentadienyl lithium compounds for self-assembly. Cyclopentadienyl (Cp) lithium derivatives are known to form [eta]⁵-coordinated, electrostatically bonded, polymeric supersandwich structures in the solid...