Upon activation by binding of insulin, the insulin receptor tyrosine kinase phosphorylates a group of proteins known as the insulin receptor substrates (IRS's). The tyrosine phosphorylated IRS's then act as docking/effector molecules for SH2...
Forest ecology -- Northeastern States. ; Forest canopy ecology -- Northeastern States. ; Forest dynamics -- Northeastern States.
In closed-canopy forests, changes in the relative abundance of tree species due to major disturbance or to its absence are thought to be governed principally by differences among component species in the performance of juveniles. However, few...
Chlorinated ethenes are ubiquitous environmental pollutants of public concern due to their potential toxicity and carcinogenicity. Under appropriate conditions anaerobic bacteria mediate the dechlorination of perchloroethylene (a common dry...
We consider a problem of information overload: the conflict between vast amounts of data available in electronic form and inadequate tools for finding relevant information. To alleviate this problem we look at the information organization:...
The thesis is devoted to the effects of electromagnetic coupling between the Earth's magnetosphere and the active auroral ionosphere. The research has been focused, in particular, on the concept of ionospheric feedback instability. The feedback...
The respiratory control network (RC) is made up nuclei dispersed throughout the pons and medulla oblongata and receives information from various sources that alter respiratory output. My studies have been focussed on one of these nuclei that play a...
Spot 14 (S14) is a ~17 KD nuclear protein that functions at the transcriptional level to regulate de novo synthesis of fatty acids in liver, brown and white adipose, and. lactating mammary tissues. Localization of the S14 gene to chromosome 11q13.5...
Multimedia systems -- Mathematical models. ; Information storage and retrieval systems. ; Machinery -- Alignment.
This thesis introduces multiple media correlation, a new technology for the automatic alignment of multiple media objects such as text, audio, and video. This research began with the question: what can be learned when multiple multimedia components...
A method for the reconstruction of a spectrum of mechanical properties from phase-contrast, MR displacement data is developed and implemented via the finite element method. To overcome the significant computational load associated with...
Partially ordered sets. ; Convex polytopes. ; Representations of groups.
This thesis deals with geometric representations of ordered sets. In a geometric representation, each element of the ordered set is assigned a geometric object, with two elements incomparable in the ordered set if and only if the corresponding...
Computer input-output equipment. ; Computational grids (Computer systems). ; High performance computing. ; Electronic data processing -- Distributed processing.
High-performance computing increasingly occurs on computational grids composed of heterogeneous and geographically distributed systems of computers, networks, and storage devices that collectively act as a single virtual computer. A key challenge...
Information resources management -- Mathematical models. ; Database management -- Methodology. ; Change. ; World Wide Web.
Many modern information management tasks consist of an observer that must maintain current knowledge of a collection of changing information. The goal of this observer is to maintain acceptably accurate state estimates given limited observation...
The thesis is dedicated to the understanding and characterization of brittle compressive fracture of columnar S2 ice. The work quantifies the strength of fresh-water S2 ice and investigates its characteristic brittle failure modes under biaxial...
Neurospora -- Genetics. ; Neurospora -- Effect of light on. ; Circadian rhythms. ; Proteins -- Synthesis -- Effect of light on. ; Genetic regulation.
The frequency gene and the two proteins it encodes are central components of the Neurospora circadian clock. The frq message and proteins are involved in a negative feedback loop in which FRO represses its own transcript level. Based on this...
The mannose-sensitive hemagglutinin (MSHA) of Vibrio cholerae is a member of the family of type 4 pili. Type 4 pili expressed on the surface of a number of Gram-negative bacteria are often required for host colonization. MSHA is specifically...
Let K be the function field over a finite field of odd order, and let H be a definite quaternion algebra over K. If Α is an order of level M in H , we define theta series for each ideal I of Α using the reduced norm on H. Using harmonic analysis...
Chronic neuropathic pain is a debilitating condition that exacts an emotional and physical toll on its sufferers and their family as well as an enormous monetary toll on society. Neuropathic pain can arise following nerve injury induced by trauma,...
APETALA3 (AP3) is a MADS box gene required for normal development of the petals and stamens in the Arabidopsis flower. AP3 transcriptional regulation occurs in two stages; an initial establishment phase, which is mediated by LEAFY (LFY) and UNUSUAL...
Nuclear magnetic resonance spectroscopy -- Data processing. ; Proteins -- Analysis -- Mathematical models. ; Computer algorithms.
Our aim is to enhance high-throughput applications of Nuclear Magnetic Resonance (NMR) through the development of efficient computational methods that operate on sparse (minimal) sets of experimental NMR data. We have developed a family of four...
Eating disorders are a persistent problem for women on college campuses across the country, and peer education programs are one method that colleges have employed to address these concerns. A previous study found that peer education is actually...
Strong evidence exists showing that stellar evolution models are unable to accurately predict the fundamental properties of low-mass stars. Observations of low-mass stars in detached eclipsing binaries (DEBs) indicate that stellar models...
For many scientific applications, the data set cannot entirely fit in main memory. The data must reside out-of-core, i.e., on parallel disks. For many basic data-movement operations such as permuting, if the programmer does not design efficient...
We prove the existence of nontrivial multiparameter isospectral deformations of metrics on the classical compact simple Lie groups SO (n) (n = 9, n ≥11), Spin(n) (n = 9, n ≥11), SU (n) (n ≥7), and Sp (n) (n ≥5). The proof breaks into three...
Novel biotherapeutics have reshaped drug discovery and promise a continued revolution in disease therapy, yet therapeutic proteins present unique design challenges. One distinguishing risk factor is the prospect of eliciting an adaptive immune...
The new APM South Equatorial Strip Catalog $({-}17\sp\circ.5<\delta<2\sp\circ.5)$ is used to select a sample of early-type galaxies in three directions: (1) 15h10-16h10; (2) 20h30-21h50; (3) 00h10-01h30. The distances and peculiar motions of...