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Subcellular location and function studies of the serum and glucocorticoid induced kinase-1 (SGK1).
Protein kinases -- Mechanism of action. Sodium channels -- Genetic aspects. Glucocorticoids. Acetylation. Histones. Sgk protein. Receptors
The serum and glucocorticoid induced kinase 1 (SGK1) is involved in aldosterone-induced Na + reabsorption by increasing epithelial Na + channel (ENaC) activity in cortical collecting duct (CCD) cells. We found the SGK1-GFP fusion protein is...
Dartmouth Dissertations

Identification of steroid-binding and phosphorylated sites within the glucocorticoid receptor
Glucocorticoids -- Receptors; Phosphorylation; Steroid-binding proteins
Dartmouth Dissertations

ACAT1 blockage stimulates autophagy to emeliorate Alzheimer's disease / by Yohei Shibuya
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia in the aging population. Currently, there is no cure for AD. The hallmark of AD consists of extracellular amyloid plaques, mainly composed...
Dartmouth Dissertations

Cellular organization in syncytia : nuclear autonomy and cytosolic organization across kingdoms / by Samantha Elizabeth Roberts
All cells must organize their cytoplasm in order to carry out functions properly and survive in different environments, and the requirement for organization is increased in large, multinucleate cells. It has long been known that membrane-bound...
Dartmouth Dissertations

Light and circadian regulation in Neurospora crassa.
Neurospora crassa -- Effect of light on. ; Neurospora crassa -- Genetics. ; Circadian rhythms. ; Genetic transcription -- Regulation. ; Cryptochrome. ; Phytochrome.
Dartmouth Dissertations

The macromolecular assembly of NuMA.
Nucleoproteins. ; Macromolecules. ; Cell organelles -- Formation. ; Mitosis. ; Phosphorylation.
Dartmouth Dissertations

An examination of Raf-1 expression and kinase activity throughout the T lymphocyte cell cycle.
Proto-oncogenes. ; T cells. ; Phosphotransferases.
Dartmouth Dissertations

Metal distribution in Arabidopsis.
Arabidopsis -- Effect of metals on. ; Zinc -- Physiological transport. ; Iron -- Physiological transport. ; Plants -- Effect of iron on. ; Plants -- Effect of zinc on.
Iron and zinc deficiency commonly limit plant growth and crop yields. Furthermore, deficiencies in both of these micronutrients are common throughout the world, particularly in developing countries where people may only consume simple diets...
Dartmouth Dissertations

Molecular analysis of heterochronic gene lin-14 and developmental cell cycle control in Caenorhabditis elegans.
Caenorhabditis elegans -- Genetics. ; Cellular control mechanisms. ; Cell cycle.
During postembryonic development of C. elegans the heterochronic gene lin-14 controls the timing of developmental events in diverse cell types. Three alternative lin-14 transcripts are predicted to encode isoforms of a novel nuclear protein that...
Dartmouth Dissertations

SGK1 is an important determinant of sodium channel activity in the mammalian collecting duct.
Aldosterone -- Mechanism of action. ; Aldosterone -- Physiological effect. ; Adrenocortical hormones -- Genetic aspects. ; Sodium channels -- Genetic aspects. ; Genetic regulation.
Hypertensive disorders, as well as congestive heart disease. Despite extensive research on the regulatory events that occur between aldosterone induced transcription and the early activation of epithelial sodium channels (ENaC ) in cortical...
Dartmouth Dissertations

Effects of mitomycin C and other DNA crosslinking agents on gene expression: modulation of cancer cell multidrug resistance in cell culture and in vivo.
Mitomycin C -- Genetic aspects. ; DNA damage. ; Drug resistance in cancer cells. ; Cancer -- Chemotherapy -- Genetic aspects.
Our laboratory is concerned whether the distribution of chemically-induced DNA damage is non-random at the level of individual genes. Using changes in gene expression as a marker for DNA damage, we have previously demonstrated that genotoxic...
Dartmouth Dissertations

The role of glia in neuropathic pain: a journey into the tetrapartite synapse.
Neuroglia -- Effect of drugs on. Astrocytes. Opioids -- Physiological effect. Central nervous system -- Pathophysiology. Nerves
Neuropathic pain is a debilitating condition that affects millions of individuals worldwide. Unfortunately, opioids are only partially effective in treating neuropathic pain while entraining tolerance and a myriad of side effects from the high...
Dartmouth Dissertations

Functions of prostacyclin in vascular and uterine smooth muscle.
Prostacyclin -- Physiological effect. Vascular smooth muscle. Vascular endothelium -- Physiology. Myometrium -- Physiology. Cardiovascular system -- Diseases. Cellular signal transduction.
Prostacyclin (PGI2) is a major product of COX-2 derived arachidonic acid metabolism in the endothelium and uterine myometrium. Evidence indicates that PGI 2 protects against development and progression of vascular disease. While it has been known...
Dartmouth Dissertations

The evolution of metazoan microRNA genes and the advent of vertebrate complexity
Vertebrates -- Evolution.;""Vertebrates -- Molecular genetics."";""Cyclostomata (Bryozoa) -- Evolution."";""Cyclostomata (Bryozoa) -- Molecular genetics."";""Metazoa -- Evolution."";""Metazoa -- Molecular genetics."";""Non-coding RNA."";""MicroRNAs...
Dartmouth Dissertations

Differential response in p53 wild-type cells to p53 activation by DNA damage and Nutlin-3
DNA damage induces cell cycle arrest through both Chk1 and the p53 tumor suppressor protein, the latter arresting cells through induction of p21waf1 protein. Arrest permits cells to repair the damage and recover. The frequent loss of p53 in tumor...
Dartmouth Dissertations

Role of Whi3 protein aggregation behavior in cell-cycle regulation and cell polarity / by ChangHwan Lee.
Whi3 is a G1/S regulator and known to inhibit G1 CDK activity. It was first described as a cell-size control gene in a set of cell division cycle mutants in Saccharomyces cerevisiae. Dysfunction or deletion of Whi3 leads to abnormal cell cycle...
Dartmouth Dissertations

MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations

Rejuvenation of cohesion during meiotic prophase is required for maintenance of chiasmata and accurate chromosome segregation / by Katherine Adalia Weng.
Accurate chromosome segregation in human oocytes requires that meiotic sister chromatid cohesion remain intact for decades and work in model organisms indicates that deterioration of meiotic cohesion over time may be a major determinant of...
Dartmouth Dissertations

Endogenous leukocyte activation by chimeric antigen receptor T cell immunotherapy / by Paul Spear.
Many protocols for adoptive T cell therapy (ACT) include preparative conditioning strategies to deplete host lymphocytes prior to T cell infusion. Total body irradiation and high-dose chemotherapy regimens not only relieve immunosuppression, but...
Dartmouth Dissertations

Laying a solid foundation for Manhattan : 'setting the functional basis for the post-GWAS era' / by Xiaoyang Zhang
Genome-wide association studies (GWAS) have identified more than 8,900 genetic variants, mainly single nucleotide polymorphisms (SNPs), associated with hundreds of human traits and diseases, which define risk-associated loci (Hindorff et al., 2012 ...
Dartmouth Dissertations

Evaluation and engineering of Saccharomyces cerevisiae for cellulase expression and growth on insoluble cellulose.
Saccharomyces cerevisiae -- Genetics. Cellulase -- Biotechnology. Cellulose -- Biotechnology. Biomass conversion -- Technological innovations.
Dartmouth Dissertations

Characterization of an inducible model of a genetic prion disease in Drosophila melanogaster / by Archana Murali.
Prion diseases are progressive disorders that affect the central nervous system leading to memory loss, personality changes, ataxia and neurodegeneration. In humans, these disorders include Creutzfeldt-Jakob disease, kuru and...
Dartmouth Dissertations

SirT1 regulates vascular smooth muscle cell plasticity : implications for age-related cardiovascular disease / by Anne Marie Thompson.
Loss of vascular smooth muscle cell function is a hallmark of vascular disease. Vascular smooth muscle cells become increasingly resistant to phenotypic modulation, apoptotic and senescent. Sirtuin 1 (SirT1) is a deactylase that regulates...
Dartmouth Dissertations

Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

Links and regulatory loops between phospholipase C activity and colonization by the O2-responsive regulator Anr in Pseudomonas aeruginosa / by Angelyca A. Jackson.
Pseudomonas aeruginosa is a virulent opportunistic pathogen that is frequently cultured from infectious sites, and is estimated to cause ~12% of nosocomial infections worldwide [1]. P. aeruginosa infections occur in a majority of adults with the...
Dartmouth Dissertations

Novel mechanisms of action of putative pro-apoptotic BH3 mimetics and their potential therapeutic use / by Ryan Scot Soderquist.
The BCL2 family of proteins control intrinsic apoptosis at the mitochondria through a delicate balance of pro and anti-apoptotic proteins. Anti-apoptotic proteins are frequently relied upon by cancer cells, making them ideal targets for...
Dartmouth Dissertations

Modulation of swarming motility in Pseudomonas aeruginosa / by Dae Gon Ha.
Swarming motility is a flagella-dependent surface motility, and is also a form of bacterial group behavior. Similar to its counterpart biofilm formation, our understanding of swarming motility has been hampered by its complex set of requirements...
Dartmouth Dissertations

The role of cell stress signalling in the induction of [gamma]-globin gene expression / by Emily K. Schaeffer.
Increased fetal hemoglobin (HbF) expression is beneficial for [beta]-hemoglobinopathy patients; however, most inducing agents do not possess the ideal combination of efficacy, safety and availability. Better understanding the mechanisms involved in...
Dartmouth Dissertations

Conformationally restricted bis(9-aminoacridine)s : a chemical and biological study
Acridine.
A series of conformationally restricted bis(9-amino-acridine) derivatives were designed, synthesized, and then evaluated for their chemical and biological behavior. The novel compounds were prepared by treating selected diamines with a...
Dartmouth Dissertations

Runx1 is required in vascular endothelial cadherin expressing cells for hematopoietic stem cell emergence.
Transcription factors. Hematopoietic stem cells -- Genetic aspects. Hematopoiesis -- Regulation. DNA-binding proteins. Vascular endothelium.
Hematopoietic stem cells (HSCs) are the cells that can give rise to all different lineages of differentiated/mature blood cells. HSCs are capable of self-renewal and maintaining the homeostasis of differentiated cells for specific functions. The...
Dartmouth Dissertations

Transcriptional regulation of the neuronal nACh receptor ?4 subunit gene.
Nicotinic receptors -- Genetic aspects. Gene expression. Molecular genetics.
Dartmouth Dissertations

Cif, a novel Pseudomonas aeruginosa toxin.
Pseudomonas aeruginosa infections -- Pathogenesis. Hydrolases. Membrane proteins -- Physiological transport. Genetic regulation. Epoxide Hydrolases -- genetics.
Pseudomonas aeruginosa is the leading cause of morbidity and mortality amongst cystic fibrosis (CF) patients. Following initial colonization of the CF lung by P. aeruginosa , the bacterium establishes chronic, long-term infections. Chronic P....
Dartmouth Dissertations

Heat shock and regulatory elements in Drosophila small hsp genes.
Heat shock proteins. Genetic transformation. Drosophila.
Dartmouth Dissertations

Disruption of the Cbfa2 or Cbfb gene causes necrosis and hemorrhages in the central nervous system and blocks definitive hematopoiesis.
Transcription factors. Genetic transcription. Hematopoiesis -- Genetic aspects. Central nervous system -- Growth -- Genetic aspects. Mice -- Nervous system -- Genetic aspects. Mammals -- Embryology -- Genetic aspects.
Dartmouth Dissertations

Characterization of proteins that bind the conserved LVb and core sequences of mammalian type C retroviral enhancers.
Proteins. Protein binding. Mouse leukemia viruses. Retroviruses.
Dartmouth Dissertations

Identification and regulation of a circadian clock protein, FRQ, and a clock-controlled protein, CCG-1, in Neurospora crassa.
Circadian rhythms. Proteins -- Synthesis -- Effect of light on. Genetic regulation. Neurospora crassa -- Reproduction -- Effect of light on. Neurospora crassa -- Genetics.
To understand how the circadian clock can temporally organize a cell, the biochemical characterization of a clock protein, FRQ, was initiated in Neurospora crassa using immunochemical techniques. FRQ accumulated in constant light to maximum levels...
Dartmouth Dissertations

Genetic inactivation of ACAT1 ameliorates the amyloid pathology and cognitive deficits in a mouse model of Alzheimer's disease.
Acyltransferases -- Genetic aspects. Enzyme inhibitors. Alzheimer's disease. Amyloid.
Acyl-CoA:Cholesterol Acyltransferases (ACATs) are key enzymes in cellular cholesterol metabolism. ACAT converts free cholesterol to cholesterol ester, which makes it more easily storable in lipid droplets. There are two ACAT genes encoding two...
Dartmouth Dissertations

Ecdysterone induced genetic reprogramming of cultured Drosophila cell lines.
Ecdysterone. Genetic regulation. Drosophila.
Dartmouth Dissertations

Cholesterol metabolism and human diseases
Cholesterol -- Metabolism. ; ATP-binding cassette transporters. ; Niemann-Pick diseases -- Genetic aspects. ; Acyltransferases. ; Pregnenolone. ; Sterols. ; Acetyl-CoA C-Acetyltransferase.
Dartmouth Dissertations

The interplay between BCL2 family members in response to pharmacologically induced apoptosis
Apoptosis.; Cancer cells -- Growth -- Regulation. ; Cellular signal transduction. ; Apoptosis Regulatory Proteins -- pharmacology. ; Proto-Oncogene Proteins c-bcl-2 -- pharmacology. ; bcl2-Associated Death Protein -- pharmacology. ; Vinblastine --...
Dartmouth Dissertations

Characterization of factors critical for initial stages of Vibrio cholerae intestinal colonization.
Vibrio cholerae -- Molecular genetics. ; Bacteria -- Adhesion. ; Virulence (Microbiology) -- Molecular aspects. ; Pili (Microbiology). ; DNA-binding proteins. ; Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of cholera in humans. Intestinal colonization occurs via ingestion of contaminated food and water and results in symptoms that include the production of the characteristic rice water stool, vomiting, and...
Dartmouth Dissertations

The importance of dosage of core binding factors α and ß in hematopoietic development.
Hematopoiesis -- Regulation. ; Transcription factors.
Core Binding Factors (CBFs) are members of a small family of transcription factors that play critical roles in a number of mammalian developmental processes. CBFs are heterodimers consisting of a CBFα subunit, which contacts and binds DNA at the...
Dartmouth Dissertations

Mechanisms of survival and persistence of Vibrio cholerae.
Vibrio cholerae -- Molecular genetics. ; Pili (Microbiology). ; Proteins -- Secretion. Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of the severe diarrheal disease cholera. Colonization of the host environment by V. cholerae requires the type IV toxin co-regulated pilus (TCP). Adequate colonization by V. cholerae is essential for cholera...
Dartmouth Dissertations

The role of the genes tra-4 and glp-5 in C. elegans development.
Caenorhabditis elegans -- Genetics. ; Caenorhabditis elegans -- Generative organs. ; Caenorhabditis elegans -- Development. ; Genetic transcription -- Regulation.
Sex determination in C. elegans leads to the development of sex-specific structures and contributes to the regulation of sexually dimorphic programmed cell death. A search for factors that regulate the sexually dimorphic cell death of the...
Dartmouth Dissertations

Biochemical studies of prion composition and conversion.
Prions. Proteins -- Conformation. Prions -- physiology. Prions -- genetics.
Prion diseases are fatal neurodegenerative disorders which affect a variety of different animal species including humans. The central pathogenic event underlying prion diseases is the conformational conversion of the cellular prion protein (PrP C )...
Dartmouth Dissertations

Mechanisms by which arsenite decreases CYP3A.
Cytochrome P-450 -- Pathophysiology. ; Cytochrome P-450 -- Genetics. ; Arsenic compounds -- Physiological effect. ; Liver cells.
Arsenic is implicated in numerous human pathologies, including cancer and several forms of liver disease. One contributing mechanism may involve alterations of CYP levels by arsenic. CYP3As are the most abundant CYP proteins in human liver and...
Dartmouth Dissertations

The role of TonB-dependent receptors and alternate sigma factors in the Bradyrhizobium japonicum/soybean symbiosis.
Rhizobium -- Genetics. Cell receptors. Transcription factors. Bacteria.
Bradyrhizobium japonicum forms a nitrogen-fixing symbiosis with soybean. Signaling events, such as production of flavonoids and Nod factor, initiate the interaction, leading to formation of specialized root organs called nodules. A B. japonicum...
Dartmouth Dissertations

A complex of the BCL2-like protein CED-9 and the BH3-only protein EGL-1 recruits DRP-1 to mitochondria and promotes mitochondrial fission
Mitochondria -- Physiology.; Fission (Biology) ; Guanosine triphosphatase. ; Caenorhabditis elegans. ; Caenorhabditis elegans Proteins -- physiology. ; GTP Phosphohydrolases -- physiology. ; bcl2-Associated Death Protein -- physiology.
Dartmouth Dissertations

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