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An evaluation of adrenergic and sympathetic influences modulating behavior in an animal model of neuropathic pain.
Neuralgia -- Animal models. Allodynia -- Animal models. Adrenergic mechanisms. Sympathetic nervous system.
Dartmouth Dissertations

Hydrophilic solute transport across the rat blood-brain barrier.
Blood-brain barrier.
Dartmouth Dissertations

Combined MRI and near-infrared spectroscopy for increased specificity of breast cancer imaging / by Michael A. Mastanduno.
A yearly breast contrast-MR scan is recommended to high-risk women because of MR's high sensitivity to breast tumors. However, breast contrast-MR yields a high number of false positives that lead to expensive and sometimes unnecessary biopsy...
Dartmouth Dissertations

Teaching diverse orthopaedic patient populations about deliberative decision making skills : testing a design strategy for online patients' decision aids
Clinical medicine -- Decision making. ; Medical informatics. ; Patient participation. ; Osteoarthritis -- Treatment. ; Knee -- Diseases -- Treatment. ; Decision Making. ; Decision Support Techniques.
Problem Statement. Effective patients' decision aids (PtDAs) help patients understand clinical information and reduce decisional conflict. PtDAs that also explicitly provide guidance through four """"Deliberative Steps"""" may achieve additional...
Dartmouth Dissertations

The mental workspace as a distributed neural network / by Alexander Schlegel
The brain is a vastly interconnected information processing network. In humans, this network supports the rich mental space at the root of the imagination and enables many flexible cognitive abilities such as scientific and artistic creativity. How...
Dartmouth Dissertations

Contributions of retrosplenial cortex to associative learning and memory.
Cerebral cortex -- Psychophysiology. Learning.
Neuroanatomical studies have defined two relatively separate corticohippocampal processing streams that contribute substantially to medial temporal lobe function. Among the cortical regions providing significant input to these processing streams is...
Dartmouth Dissertations

The dorsal tegmental nucleus of Gudden and angular velocity integration in the head direction system.
Space perception. ; Motion perception (Vision). ; Vestibular apparatus.
Head Direction (HD) cells are neurons located primarily in the limbic system that fire as a function of directional heading in the horizontal, or yaw, plane in the freely moving animal. Our hypothesis is that the HD signal is the result of two...
Dartmouth Dissertations

Behavioral and neural investigations of behaviorally relevant features of auditory stimuli.
Auditory pathways -- Physiology. ; Auditory perception -- Physiological aspects. ; Directional hearing -- Physiological aspects. ; Speech perception -- Physiological aspects. ; Prefrontal cortex -- Physiology. ; Parietal lobes -- Physiology. ;...
Studies of the structure and function of the human and non-human primate auditory system have led to the hypothesis that it is composed of dorsal and ventral processing streams that are respectively dedicated to spatial and non-spatial processing....
Dartmouth Dissertations

Characterization of pathways and intermediates involved in CD40 signal transduction.
CD antigens. ; Cellular signal transduction. ; Immune response -- Regulation. ; Antigens CD40.
Dartmouth Dissertations

Representation of auditory and visual spatial information in the intraparietal sulcus of rhesus macaques.
Auditory perception -- Physiological aspects. ; Visual perception -- Physiological aspects. ; Auditory pathways -- Physiology. ; Parietal lobes -- Psychophysiology. ; Saccadic eye movements.
The integration of visual and auditory events is thought to require a joint representation of visual and auditory space in a common reference frame. We investigated the coding of visual and auditory space in the lateral and medial intraparietal...
Dartmouth Dissertations

Hemispheric differences in visual information processing.
Human information processing. ; Cerebral hemispheres. ; Visual perception.
Dartmouth Dissertations

The effect of epileptiform activity and seizures during development on the prefrontal cortex and cognition / by Amanda Erin Hernan.
Epilepsy is the most common neurological disorder in children, with an incidence of 100 per 100,000 children per year. Recurrent seizures during this period in life are often distressing to the individual and the family, but arguably the most...
Dartmouth Dissertations

Acquisition and registration of 3D optical surface scanning, MRI, and microwave tomographic imaging for improved clinical breast imaging and surgical planning / by Matthew John Pallone.
Continual improvements to clinical breast imaging technologies have led to ever earlier detections and increasingly accurate localizations of female breast cancers. While these advancements have certainly improved the prognoses of many patients,...
Dartmouth Dissertations

Brain repair after trauma : birth and migration of immature neurons after focal traumatic brain injury in piglets and human children / by Sabrina Rose Taylor.
Traumatic brain injury (TBI) is the leading cause of acquired disability in children, yet innate repair mechanisms are incompletely understood. A possible innate mechanism to repair injury after insult is neurogenesis - the birth, migration,...
Dartmouth Dissertations

Effects of mesencephalic reticular formation and mesencephalic auditory pathway lesions on long- and short-term habituation processes in the rat.
Habituation (Neuropsychology) Mesencephalon. Rats as laboratory animals.
Dartmouth Dissertations

The problems of perception and regulation in the relationship between activities and mood.
Mood (Psychology)
Dartmouth Dissertations

Traces on graph algebras / by Danny W. Crytser.
This thesis contains material relating to two separate subjects. The first section determines when the C*-algebra affiliated to a directed graph has continuous trace. We use groupoid methods and the focus is on producing conditions on a graph that...
Dartmouth Dissertations

The role of DEG/ENaC ion channel subunits in pheromone detection and mating behaviors in Drosophila melanogaster / by Vinoy Vijayan.
Gustatory pheromones regulate mating behaviors in Drosophila melanogaster and represent an important model for understanding how sensory stimuli can drive behavior. However, the genes and cells involved in pheromone detection have remained poorly...
Dartmouth Dissertations

Memory consolidation in temporal lobe epilepsy / by Ali Seçkin Titiz.
Epilepsy is associated with cognitive impairments which often manifest as a higher prevalence of memory impairments. Memory impairments in patients with epilepsy may persist even with sufficient control of seizures, suggesting other factors may...
Dartmouth Dissertations

The causes and consequences of regulation of [Delta]NP63[alpha] in mammary and breast cancer stem cells / by Andrew Joseph DeCastro.
Despite the array of targeted therapeutics that currently exist to combat breast cancer, disease progression leading to metastasis, and tumor recurrence still remains a significant clinical challenge. Efforts to identify novel pathways and...
Dartmouth Dissertations

Exercise and the brain : impacts on cognition neural function and mental health / by Andrea M. Robinson.
It has been well established that physical exercise has broad impacts across the lifespan, including improved cognition, brain function, and mental health. Studies investigating the mechanism underlying the cognitive enhancing effect of exercise...
Dartmouth Dissertations

Role of NA[subscript v]1.1 in septo-hippocampal coordination of theta rhythm and spatial memory : implications for cognitive deficits in Dravet syndrome / by Alex C. Bender
In the nervous system, neuronal communication relies critically on the function of membrane ion channels. One of these is the voltage-gated sodium channel (VGSC), which is essential for the generation and propagation of action potentials in...
Dartmouth Dissertations

Shared decision making for people with severe mental illness.
Mentally ill -- Care -- Decision making. Mental illness -- Treatment -- Decision making. Mental health services -- Decision making. Mental health -- Information services. Medical informatics. Mental Disorders -- drug therapy.
Objective. We explored preferences and perceptions about treatment decision-making roles among persons with severe mental illness and evaluated two computer-based medication values clarification tools. Methods. In this study we conducted a pilot...
Dartmouth Dissertations

The effects of brain damage on source monitoring.
Brain damage -- Psychological aspects. Memory. Brain -- Localization of functions. Neuropsychology.
Two experiments were designed to investigate the effects of brain damage on source monitoring. Source monitoring is the process of making decisions about the origins of memories. Previous research has demonstrated that source monitoring judgments...
Dartmouth Dissertations

Neural and behavioral correlates of auditory-object processing.
Auditory perception. Temporal lobes -- Physiology. Prefrontal cortex -- Physiology. Neurophysiology.
The neurophysiological examination of auditory-object representations has focused on how early auditory cortical areas code for the spectral and temporal features of auditory objects. The goals of this dissertation was to investigate how auditory...
Dartmouth Dissertations

Bilingual and monolingual brains compared: a fMRI study of semantic processing.
Bilingualism -- Physiological aspects. ; Neurolinguistics. Cognition -- Physiological aspects. ; Brain -- Localization of functions.
Does early and sustained experience with two languages in childhood modify how language is processed in the adult bilingual brain? Does extensive exposure to two languages influence language processing in the bilingual brain as compared to...
Dartmouth Dissertations

Facial expressions and identity as social cues for biologically relevant learning
Facial expression.; Threat (Psychology) ; Amygdaloid body -- Psychophysiology. ; Learning Psychology of. ; Memory. ; Attention.
The experiments comprising this thesis aimed to characterize the neural and behavioral correlates of learning about and responding to the predictive information conveyed by social cues. Facial expressions are cues that convey critical information...
Dartmouth Dissertations

$Influence of the infracerebellar nucleus on respiratory activity.$
Influence of the infracerebellar nucleus on respiratory activity.
Respiration -- Regulation. ; Cerebellar nuclei.
Dartmouth Dissertations

An analysis of the locomotive stimulant and the ECoG effects of L-DOPA.
L-dihydroxphelylalanine. ; Amphetamines.
Dartmouth Dissertations

Forebrain mechanisms of conditional hypoalgesia: involvement of the amygdala.
Analgesia. ; Amygdaloid body.
Dartmouth Dissertations

Using the eyes to measure the mind : pupil dialation dynamics as a biomarker of online attention / by Olivia E. Kang
Every moment of our waking lives, our brains filter large quantities of sensory data for goal relevant information. This ability to modulate our sensitivity to incoming inputs is critical in the face of an otherwise overwhelming world, and...
Dartmouth Dissertations

Reciprocal benefits in a plant-pollinator mutualism.
Mutualism (Biology). Insect-plant relationships. Insect population density. Bumblebees -- Ecology. Delphinium -- Ecology.
Mutualisms may facilitate coupled population expansion or decline if changes in either partner species lead to similar changes in the other species. However, few studies have measured how both species in a mutualism respond to changes in each...
Dartmouth Dissertations

The functional importance of the head direction signal for homing behavior / by William Nelson Butler
The rat limbic system contains head direction (HD) cells that fire according to heading in the horizontal plane. These HD cells are thought to provide animals with an internal compass to guide navigation. Previous work has found that HD cell tuning...
Dartmouth Dissertations

The mechanism of action for angiotensin-1-7 in the rostral ventrolateral medulla in the modulation of cardiovascular sympathetic nerve activity / by Mark S. Bilodeau
Elevated sympathetic discharge from the CNS is an underlying pathogenic mechanism in neurogenic hypertension and an exacerbating factor in chronic heart failure (CHF). Current treatment of these diseases focuses on attenuation of the downstream...
Dartmouth Dissertations

Serotonin signaling in the nucleus tractus solitarius modulates the larybgeal chemoreflex : implications for sudden infant death syndrome / by William T. Donnelly
Sudden infant death syndrome (SIDS) occurs when a sleeping infant experiences a challenge to cardiorespiratory homeostasis which it fails to overcome. Analyses of brain tissue from SIDS cases from around the world consistently show abnormalities in...
Dartmouth Dissertations

Subtypes of developmental prosopagnosia : behavioral and neural evidence / by Hua Yang
Developmental prosopagnosia (DP) is a neurodevelopmental disorder defined by impaired face recognition in the absence of brain damage, low-level visual deficits, or broad cognitive problems. Behavioral and neural findings suggest different types of...
Dartmouth Dissertations

Targeting kinetochore-microtubule stability affects chromosome segregation and tumor growth in mice / by Christopher D. Laucius
Chromosomal instability (CIN) is defined as a high rate of whole chromosome loss or gain and is a hallmark of many aneuploid solid tumors. CIN positively correlates with poor patient prognosis and chemotherapeutic resistance. The persistence of...
Dartmouth Dissertations

Methods for rapid EEG-based mapping of human brain functions.
Electroencephalography. ; Brain mapping -- Methodology. ; Evoked potentials (Electrophysiology).
Brain mapping via EEG activation is a useful tool of basic neuroscience, and has wide clinical applications as well. The mapping is achieved by means of Event Related Potentials (ERPs), task-related changes in EEG time series. The methodology of...
Dartmouth Dissertations

Sensing eye position.
Saccadic eye movements. ; Eye -- Movements. ; Visual perception -- Physiological aspects. ; Senses and sensation.
The oculomotor system needs up-to-date information about eye position in order to make accurate saccades to stimuli in the environment. This thesis investigated how well the oculomotor system uses information about eye position to make a variety of...
Dartmouth Dissertations

Market-based control of mobile-agent systems.
Mobile agents (Computer software). ; Resource allocation -- Mathematical models. ; Computer networks -- Economic aspects.
Modern distributed systems scatter sensors, storage, and computation throughout the environment. Ideally these devices communicate and share resources, but there is seldom motivation for a device''s owner to yield control to another user. We...
Dartmouth Dissertations

Ionic basis of neuronal CO²/H+ chemosensitivity in the pulmonate snail, Helix aspersa.
Hypercapnia -- Regulation. ; Carbon dioxide -- Physiological effect. ; Carbon dioxide in the body. ; Brown garden snail -- Respiration. ; Potassium channels.
After more than 150 years of studying the respiratory effects of hypercapnia, the intrinsic neuronal mechanism by which carbon dioxide (CO²) stimulates electrical excitability of respiratory neurons, and hence respiratory drive, is still...
Dartmouth Dissertations

Neuroimmune and behavioral responses to peripheral nerve injury in the rat.
Nerves. ; Peripheral -- Pathophysiology. ; Nervous system -- Diseases -- Immunological aspects. ; Spinal cord -- Pathophysiology. ; Pain -- Physiological aspects. ; Rats -- Nervous system -- Diseases -- Immunological aspects. ; Rats -- Behavior.
The pain that follows nerve injury is chronic and consistently refractory to available analgesics. Neuropathic pain syndromes include deafferentation pain, diabetic, cancer and ischemic neuropathies, phantom limb pain, trigeminal neuralgia,...
Dartmouth Dissertations

The relationship between the apomorphine and the narcotic receptors of the emetic chemoreceptor trigger zone of the cat.
Emetics. ; Apomorphine. ; Morphine.
Dartmouth Dissertations

A comparison of the acute toxicity and teratogenic effects of succinonitrile and tetramethylsuccinonitrile: the role of cyanide.
Nitriles -- Toxicology. ; Teratogenic agents. ; Cyanides -- Toxicology.
Dartmouth Dissertations

The functional roles of the rostral pons in the control of respiration in mammals.
Respiration -- Regulation. ; Cats -- Respiration. ; Rats -- Respiration. ; Pons Varolii -- Physiology.
Dartmouth Dissertations

Bethanechol and central respiratory control.
Bethanechol. ; Anesthetics.
Dartmouth Dissertations

Individual differences in callosal organization: relationship to interhemispheric communication and hemispheric asymmetries.
Corpus callosum -- Physiology. Cerebral hemispheres. Laterality. Sensorimotor integration. Brain -- Localization of functions.
The overarching goal of the dissertation was to further understanding of the relationship between callosal organization, functional lateralization, and interhemispheric communication in the healthy, young adult brain. Three converging methodologies...
Dartmouth Dissertations

Identification of risk factors and etiology of strokes after CABG surgery.
Coronary artery bypass -- Evaluation. ; Cardiovascular system -- Diseases -- Risk factors. ; Cardiovascular system -- Diseases -- Etiology. ; Outcome assessment (Medical care).
Coronary artery bypass graft (CABG) surgery is a leading treatment option for extending and/or improving the quality of life for patients suffering from heart disease. While we have witnessed improvements in mortality and morbidity secondary to...
Dartmouth Dissertations

Development and quantification of a 3D brain deformation model for model-updated image-guided stereotactic neurosurgery.
Three-dimensional imaging in medicine -- Mathematical models. ; Stereoencephalotomy.
In the past, clinicians skilled at image-guided neurosurgery have relied solely on pre-operative scans for their navigational information. Often in the course of surgery, tissue is purposely retracted/resected or inadvertently moved resulting in a...
Dartmouth Dissertations

Distinct neuroimmune interactions in acute inflammatory pain and persistent neuropathic pain.
Pain -- Immunological aspects. ; Inflammation -- Immunological aspects. ; Nervous system -- Diseases -- Immunological aspects. ; Neuroimmunology.
Chronic neuropathic pain is a debilitating condition that exacts an emotional and physical toll on its sufferers and their family as well as an enormous monetary toll on society. Neuropathic pain can arise following nerve injury induced by trauma,...
Dartmouth Dissertations

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