Dartmouth Digital Library Program

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Flow of bubbles through nozzles.
Two-phase flow -- Mathematical models. ; Bubbles.
Dartmouth Dissertations

A new vortex model for free boundary layer flows.
Fluid dynamics. ; Vortex-motion. ; Boundary layer.
Dartmouth Dissertations

Role of Whi3 protein aggregation behavior in cell-cycle regulation and cell polarity / by ChangHwan Lee.
Whi3 is a G1/S regulator and known to inhibit G1 CDK activity. It was first described as a cell-size control gene in a set of cell division cycle mutants in Saccharomyces cerevisiae. Dysfunction or deletion of Whi3 leads to abnormal cell cycle...
Dartmouth Dissertations

The role of Estradiol in the regulation of the secretory immune system in the female reproductive tract.
Estradiol. Generative organs Female -- Secretions. Generative organs
Dartmouth Dissertations

Reconstitution and partial purification of acyl-coenzyme A:cholesterol acyltransferase and investigations of the enzyme's activity in cultured cells after reconstitution in lipid vesicles.
Acyltransferases. Esterification. Cholesterol -- Metabolism.
Dartmouth Dissertations

Cholesterol metabolism and human diseases
Cholesterol -- Metabolism. ; ATP-binding cassette transporters. ; Niemann-Pick diseases -- Genetic aspects. ; Acyltransferases. ; Pregnenolone. ; Sterols. ; Acetyl-CoA C-Acetyltransferase.
Dartmouth Dissertations

Biochemical studies of prion composition and conversion.
Prions. Proteins -- Conformation. Prions -- physiology. Prions -- genetics.
Prion diseases are fatal neurodegenerative disorders which affect a variety of different animal species including humans. The central pathogenic event underlying prion diseases is the conformational conversion of the cellular prion protein (PrP C )...
Dartmouth Dissertations

Emergent coherent structures in nonequilibrium field theory.
Coherent states. Quantum field theory. Nonlinear theories.
In this thesis we study the properties of time-dependent, nontopological configurations and their effect on the macroscopic properties of a system described by a nonlinear field theory. These structures seem to be ubiquitous in relativistic field...
Dartmouth Dissertations

Clay mineralogy and geochemistry of soils and sediments with perma frost in interior Alaska.
Clay minerals -- Alaska. ; Soils -- Alaska. ; Frozen ground -- Alaska.
Dartmouth Dissertations

The purification and partial characterization of a reconstitutively active iron-sulfur protein.
Cytochrome c. ; Iron-sulfur proteins. ; Proteins -- Analysis.
Dartmouth Dissertations

Biophysical analysis of the role of γc in the assembly of the interleukin-2 receptor.
Interleukin-2. ; T cells -- Receptors. ; Structure-activity relationships (Biochemistry). ; Biophysics.
Dartmouth Dissertations

Effect of the air-sea heat flux on the North Atlantic circulation and the Gulf Stream system.
Ocean circulation -- North Atlantic Ocean -- Mathematical models. ; Gulf Stream -- Effect of atmospheric temperature on -- Mathematical models.
Dartmouth Dissertations

Genetic variants among G-protein coupled receptors and implications for cardiovascular disease.
G proteins -- Receptors. Cardiovascular system -- Diseases -- Genetic aspects. Medical Term Receptors, G-Protein-Coupled -- genetics.
Single-nucleotide polymorphisms (SNPs), particularly non-synonymous variants, provide opportunities for deciphering pathophysiological protein influence. An ideal group for realizing these opportunities is the GPCR-superfamily. Principles from...
Dartmouth Dissertations

Feasibility testing for magneto-optic ring cellular automata.
Cellular automata. Magnetooptical devices -- Testing. Thin film devices -- Testing.
The feasibility of a magnetic computation system was tested that consists of arranging thin film micromagnetic ring structures. Each ring is magnetized in a circular, vortex state in either the clockwise (CW) or counterclockwise (CCW) directions,...
Dartmouth Dissertations

Investigating the scale-up of anaerobic soluble sugar fermentations for large-scale ethanol production.
Alcohol -- Synthesis -- Computer simulation. Corn -- Biotechnology. Fermentation -- Computer simulation. Alcohol as fuel. Computational fluid dynamics.
Renewable energy sources are becoming increasingly important as sustainable alternatives to fossil fuels. One of these renewable sources, cellulosic biomass, is a relatively inexpensive and abundant resource that can be converted into liquid fuels...
Dartmouth Dissertations

Alterations in the production of bacteriochlorophyll a and okenone in purple sulfur bacteria : implications for the interpretaion of their biomarkers / by Derek A. Smith.
Purple sulfur bacteria (PSB) can dominate the nitrogen, carbon, and sulfur cycles in anoxic ecosystems via their anoxygenic photosynthetic metabolisms and are the only producers of the carotenoid, okenone, a biomarker targeted for photic zone...
Dartmouth Dissertations

Examining auroral downward current region processes using ground based data.
Auroras -- Alaska -- Observations. Magnetospheric currents.
This thesis presents data from ground camera observations of the aurora conducted from Alaska during the winters of 2005 through 2007. In conjunction with these camera observations, conjugate radar observations of the auroral ionosphere were...
Dartmouth Dissertations

A prediction of the interaction of a normal shock with a separating, turbulent boundary layer.
Shock waves. Turbulent boundary layer.
Dartmouth Dissertations

Capillary flow of superfluid helium at 0.45°K.
Superfluidity. Liquid helium.
Dartmouth Dissertations

Analytical and computational approaches for quantitative phosphoproteomics / by Jason M. Gilmore.
Protein phosphorylation is an important regulatory mechanism for the control of countless processes in living systems. The delicate management of phosphate attachment to, and removal from, serine, threonine and tyrosine residues in proteins...
Dartmouth Dissertations

Fusion proteins and select lipids cooperate as membrane receptors for the soluble snare Vam7p / by Vidya Karunakaran.
Yeast vacuole fusion involves three transmembrane SNAREs and a unique soluble SNARE, Vam7p. This SNARE cycles between vacuolar membrane-bound and cytosolic state. In its membrane-bound state, it is able to participate in vacuolar fusion by...
Dartmouth Dissertations

The role of mediator in white-opaque switching / by Anda Zhang.
The multisubunit eukaryotic Mediator complex integrates diverse positive and negative gene regulatory signals and transmits them to the core transcription machinery. It is also involved in chromatin structure related epigenetic silencing through...
Dartmouth Dissertations

Novel dimensions in a fluid genome : an integrative risk analysis for cancers of the bladder and breast / by Asaf Wyszynski.
The present thesis is focused on developing a better understanding of factors driving disease biology and overall risk using cancers of the bladder and breast as model systems. As no single approach was likely to unravel the complexities of these...
Dartmouth Dissertations

Development of an apparatus for simultaneous trapping of ⁶Li-⁸⁷Rb Fermi-Bose mixtures.
Trapped ions -- Instruments. Magnetooptical devices -- Design and construction. Atoms -- Cooling. Lithium ions. Rubidium -- Isotopes.
Dartmouth Dissertations

A numerical simulation of tokamak sawteeth.
Magnetohydrodynamics -- Mathematical models. Tokamaks -- Mathematical models.
Dartmouth Dissertations

Conformationally restricted bis(9-aminoacridine)s : a chemical and biological study
Acridine.
A series of conformationally restricted bis(9-amino-acridine) derivatives were designed, synthesized, and then evaluated for their chemical and biological behavior. The novel compounds were prepared by treating selected diamines with a...
Dartmouth Dissertations

Supercritical states of two-dimensional wall-bounded shear flow.
Viscous flow -- Mathematical models. Navier-Stokes equations -- Numerical solutions. Reynolds number.
Dartmouth Dissertations

Identification and regulation of a circadian clock protein, FRQ, and a clock-controlled protein, CCG-1, in Neurospora crassa.
Circadian rhythms. Proteins -- Synthesis -- Effect of light on. Genetic regulation. Neurospora crassa -- Reproduction -- Effect of light on. Neurospora crassa -- Genetics.
To understand how the circadian clock can temporally organize a cell, the biochemical characterization of a clock protein, FRQ, was initiated in Neurospora crassa using immunochemical techniques. FRQ accumulated in constant light to maximum levels...
Dartmouth Dissertations

Self-consistent steady-state model of the low-lattitude boundary layer.
Magnetopause -- Mathematical models. Solar wind -- Mathematical models. Magnetosphere -- Mathematical models.
Dartmouth Dissertations

The occurrence of amino acid activating enzymes and transfer RNA in rat liver mitochondria.
Mitochondria. Enzymes. ; Rats.
Dartmouth Dissertations

Computational methods for microwave medical imaging.
Microwave imaging -- Mathematics. ; Three-dimensional imaging -- Mathematics. ; Image reconstruction -- Mathematics. ; Microwave imaging in medicine. ; Computer algorithms.
Medical imaging methods have become increasingly important in diagnosing diseases and assisting therapeutic treatment. In particular, early detection of breast cancer is considered as a critical factor in reducing the mortality rate of women....
Dartmouth Dissertations

Comparison of the Torpedo and mammalian postsynaptic 43K protein and its relationship to the nicotinic acetylcholine receptor.
Nicotinic receptors. ; Acetylcholine -- Receptors. ; Neuromuscular transmission. ; Myoneural junction. Proteins.
Dartmouth Dissertations

Asymptotic methods for nonlinear magnetospheric boundary waves.
Magnetohydrodynamics -- Mathematical models. ; Nonlinear waves -- Mathematical models. ; Asymptotic expansions.
Dartmouth Dissertations

Functionalization of fluorocarbons.
Fluorocarbons -- Synthesis. Fluorocarbons -- Derivatives. Activation (Chemistry). Polytef -- Surfaces. Organofluorine compounds -- Synthesis.
The great strength of the C-F bond has enabled fluorocarbons to find many industrial and domestic applications, and makes C-F activation a chemical and technical challenge akin to that of C-H bond activation in hydrocarbons. In our mission to...
Dartmouth Dissertations

Identification of signaling pathways coordinating cell growth and division in fission yeast / by Lin Deng
Cell growth and division are coordinated to keep homeostasis of cell size. The components of the core machinery are conserved in a wide range of cell types. Fission yeast (S. pombe) has been an important model organism to study cell size control...
Dartmouth Dissertations

High-throughput analysis of antigen-specific antibody effector function from polyclonal Ig / by Eric Brown
Antibodies are known to be a primary correlate of protection in almost all current vaccines, and thus evaluating the antibody response is of critical importance in attempting to predict the efficacy of novel vaccine candidates. Historically...
Dartmouth Dissertations

Superconducting single electron transistor for charge sensing in Si/SiGe-based quantum dots / by Zhen Yang
Si-based quantum devices, including Si/SiGe quantum dots (QD), are promising candidates for spin-based quantum bits (quits), which are a potential platform for quantum information processing [1]. Meanwhile, qubit readout remains a challenging task...
Dartmouth Dissertations

Uncovering the mechanisms controlling metal micronutrient homeostasis in plants / by Amanda L. Socha
As the human population increases, it is imperative that we develop strategies to improve agricultural productivity to meet the growing demand for food, fuel and fiber. More than 2 billion people suffer from "hidden hunger" (a lack of essential...
Dartmouth Dissertations

How sea ice microstructure influences the polar transport of salts from the ocean into the atmosphere / by Ross Lieb-Lappen
Sea ice appears to form an impenetrable boundary at the ocean-atmosphere interface in polar regions, yet in fact its porous structure provides critical pathways for the exchange of heat, gases, salts, and other chemical species impacting the global...
Dartmouth Dissertations

Environmental and climatic controls on glaciochemistry of near-surface snow in Greenland / by Gifford J Wong
Arctic temperature and precipitation have been rising over recent decades, with implications for Greenland Ice Sheet (GrIS) mass balance, sea level rise, and thermohaline circulation via Arctic Ocean freshening. However, meteorological station data...
Dartmouth Dissertations

Plasmodium falciparum SERA protein transgenics used in the study of parasite immunobiology and drug resistance.
Plasmodium falciparum -- Immunological aspects. ; Plasmodium falciparum -- Genetics. ; Toxoplasma gondii -- Genetics. ; Serine proteinases. ; Transgenic organisms. ; Drug resistance in microorganisms -- Genetic aspects.
Genetic and immunological tools have been used to study two protozoan parasites, Plasmodium falciparum and Toxoplasma gondii. Toxoplasma gondii provides an excellent model for the study of protozoan parasite biology. Plasmodium falciparum causes...
Dartmouth Dissertations

Inertial coupling in two-phase flow: a few test cases and their impacts on two-fluid modeling.
Two-phase flow. ; Couplings.
Dartmouth Dissertations

Biochemical characterization of recombinant acyl coenzyme A:cholesterol acyltransferase expressed in insect Sf9 cell.
Acyltransferases. ; Enzymatic analysis. ; Cholesterol -- Metabolism -- Regulation. ; Cholesterol -- Synthesis -- Regulation. ; Genetic recombination.
Dartmouth Dissertations

Properties of Rathke's pouch.
Pituitary gland. ; Hypothalamus. ; Rats.
Dartmouth Dissertations

Methods for prevention of oral Toxoplasma gondii infection-induced hyperimmune response in mice.
Toxoplasma gondii. ; Biological response modifiers. ; Immune response -- Regulation. ; Toxoplasmosis -- Immunotherapy. ; Interleukin-10 -- therapeutic use. ; Cholera Toxin -- therapeutic use. ; Anti-Inflammatory Agents -- therapeutic use.
Dartmouth Dissertations

New measurements of equatorial spread-F: high-altitude irregularities and drifting bubbles.
Plasma instabilities. ; Ionospheric electron density. ; Ionosphere.
As a result of an unstable plasma stratification the nighttime equatorial ionosphere is subject to a variety of plasma instabilities known commonly as equatorial spread-F. In its fully developed form spread-F consists of large wedges of depleted...
Dartmouth Dissertations

Computations of wall-bounded two-dimensional turbulence.
Turbulence. ; Navier-Stokes equations -- Numerical solutions. ; Galerkin methods. ; Boundary layer -- Mathematical models. ; Viscous flow -- Mathematical models.
Dartmouth Dissertations

Study of the molecular mechanism of the Neurospora circadian clock.
Neurospora -- Genetics. ; Neurospora -- Effect of light on. ; Circadian rhythms. ; Proteins -- Synthesis -- Effect of light on. ; Genetic regulation.
The frequency gene and the two proteins it encodes are central components of the Neurospora circadian clock. The frq message and proteins are involved in a negative feedback loop in which FRO represses its own transcript level. Based on this...
Dartmouth Dissertations

Vibrio cholerae H-NS: investigation of regulated genes and structure-function analysis.
Vibrio cholerae -- Genetics. ; DNA-binding proteins. ; Genetic transcription -- Regulation. ; Bacterial proteins.
H-NS, an abundant nucleoid associated protein, has a role in silencing the expression of a variety of environmentally regulated genes during growth under nonpermissive conditions. A genetic approach was used to study H-NS regulation of genes in...
Dartmouth Dissertations

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