Dartmouth Digital Library Program

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The impact of weakly coupled fields on the accelerated expansion and its observables / by Jannis Bielefeld
The accelerated expansion of space in the Universe has been known for two decades. However, finding a plausible theory that describes this expansion is more difficult: Taking general relativity for granted requires us to stipulate the existence of...
Dartmouth Dissertations

Link prediction for network data / by Ye Xu
Networks that model relationships in the real world have attracted much attention in the past few years. The "link prediction problem" plays a central role in the network area. In this thesis, we explore the link prediction problem in a...
Dartmouth Dissertations

Analysis of inpatient surveillance data for automated classification of deterioration.
Problem Statement Patient safety in the modern hospital is supported by multiple human and technological systems, and this type of high-risk/high-complexity domain requires multiple layers of protection against harm. This fault-tolerant approach is...
Dartmouth Dissertations

Using theory to predict phase behaviour in liquids, copolymer melts, and ultrathin polymer films / by Nicholas B. Tito.
Thermodynamics, and the classic balance between entropy and enthalpy, provides a proverbial zoo of exotic phase behaviour that chemists can harness to create new materials out of simple liquids and polymers. The diversity of self-assembling...
Dartmouth Dissertations

Crevasse detection in ice sheets using ground penetrating radar and machine learning / by Rebecca M. Williams.
The purpose of this thesis is to describe methods for detecting hidden crevasses on glaciers in Polar regions. Crevasses form in ice sheets as a result of forces imposed upon the brittle ice. The crevasses are hidden from view by bridges of soft...
Dartmouth Dissertations

Spectral analysis of moderate length time series.
Time-series analysis. Spectral theory (Mathematics).
Dartmouth Dissertations

Delayed visual feedback and visual-motor control.
Feedback (Psychology); Visual evoked response. Motor ability.
Dartmouth Dissertations

System and methodology for receptor-level fluorescence imaging during surgery / by Kristian Sexton.
Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted...
Dartmouth Dissertations

SirT1 regulates vascular smooth muscle cell plasticity : implications for age-related cardiovascular disease / by Anne Marie Thompson.
Loss of vascular smooth muscle cell function is a hallmark of vascular disease. Vascular smooth muscle cells become increasingly resistant to phenotypic modulation, apoptotic and senescent. Sirtuin 1 (SirT1) is a deactylase that regulates...
Dartmouth Dissertations

Understanding PDZ affinity and selectivity: all residues considered / by Jeanine F. Amacher.
PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
Dartmouth Dissertations

Souslin trees and degrees of constructibility.
Constructibility (Set theory). Trees (Graph theory).
This thesis investigates possible initial segments of the degrees of constructibility. Specifically, we completely characterize the structure of degrees in generic extensions of the constructible universe L via forcing with Souslin trees. Then we...
Dartmouth Dissertations

Analytical and computational approaches for quantitative phosphoproteomics / by Jason M. Gilmore.
Protein phosphorylation is an important regulatory mechanism for the control of countless processes in living systems. The delicate management of phosphate attachment to, and removal from, serine, threonine and tyrosine residues in proteins...
Dartmouth Dissertations

Memory consolidation in temporal lobe epilepsy / by Ali Seçkin Titiz.
Epilepsy is associated with cognitive impairments which often manifest as a higher prevalence of memory impairments. Memory impairments in patients with epilepsy may persist even with sufficient control of seizures, suggesting other factors may...
Dartmouth Dissertations

Sex-specific interactions of anabolic androgenic steroids with voluntary exercise and chronic alcohol consumption on anxiety-like behaviors in mice (Mus musculus) / by Marie Morenike Onakomaiya.
The overarching goal of this thesis was two-fold. First, to determine if the effects of chronic anabolic androgenic steroid (AAS) treatment on anxiety-like behaviors are sex-specific and second to determine how different environmental modulators...
Dartmouth Dissertations

Nerve growth factor and the septohippocampal system / by Lan Guo.
Nerve growth factor (NGF), the prototypic neurotrophin, is well characterized for its pro-survival and growth effects in sympathetic and sensory neurons. Acting as a target-derived factor, NGF regulates the maturation of innervating neurons, and...
Dartmouth Dissertations

The role of gut commensals in regulating susceptibility to acute liver damage / by Stela Celaj.
Liver disease of different etiologies confers significant morbidity and mortality and hence it constitutes a major health concern worldwide. Stemming from a range of causes, such as viral, drug-induced, alcoholic, or autoimmune, the rate of...
Dartmouth Dissertations

Modulation of swarming motility in Pseudomonas aeruginosa / by Dae Gon Ha.
Swarming motility is a flagella-dependent surface motility, and is also a form of bacterial group behavior. Similar to its counterpart biofilm formation, our understanding of swarming motility has been hampered by its complex set of requirements...
Dartmouth Dissertations

Computational methods for the discovery and application of protein sequence-structure-function relationships / by Lu He.
Proteins are ubiquitous in cells and are essential to a wide range of biological processes. Since existing proteins occupy only a small portion of the space of possible amino acid composition, understanding their sequence-structure-function...
Dartmouth Dissertations

Small molecule modulation of morphology and metabolism in Candida albicans / by Allia Kaye Smith
Candida albicans is a fungal species that naturally exists as a commensal member of the human microbiota, but can assume a pathogenic lifestyle and subsequently induce life-threatening systemic infections. The ability of the fungus to grow in...
Dartmouth Dissertations

Assortativity and the robustness of gene regulatory networks / by Dov A. Pechenick.
Robustness to genetic perturbations is a fundamental property of all living things. The genetic code is degenerate, RNA secondary structure is robust to sequence changes, and protein structure is robust to amino acid substitutions. Complex systems...
Dartmouth Dissertations

On the nature mechanisms and neural correlates of visual feature conjunction learning / by Eric Andrew Reavis.
Visual searches for a conjunction of features (e.g., a particular combination of color and shape) are ordinarily slow and difficult. However, search efficiency for a particular conjunction can improve dramatically within a few hundred practice...
Dartmouth Dissertations

Habitat selection in the American redstart (Setophaga ruticilla): the importance of early successional habitat and the role of landscape change in population declines.
Wood warblers -- Habitat. Wood warblers -- Effect of habitat modification on. Forest ecology -- New Hampshire. Animal populations -- Mathematical models.
Dartmouth Dissertations

A numerical simulation of tokamak sawteeth.
Magnetohydrodynamics -- Mathematical models. Tokamaks -- Mathematical models.
Dartmouth Dissertations

Reactive intermediates in chromium carcinogenesis.
Chromium -- Toxicology. Carcinogenesis.
Dartmouth Dissertations

Cif, a novel Pseudomonas aeruginosa toxin.
Pseudomonas aeruginosa infections -- Pathogenesis. Hydrolases. Membrane proteins -- Physiological transport. Genetic regulation. Epoxide Hydrolases -- genetics.
Pseudomonas aeruginosa is the leading cause of morbidity and mortality amongst cystic fibrosis (CF) patients. Following initial colonization of the CF lung by P. aeruginosa , the bacterium establishes chronic, long-term infections. Chronic P....
Dartmouth Dissertations

Distribution of sessile rotifers in a bog pond : with particular emphasis on substrate selection by Ptycura Beauchampi larvae
Rotifera. Ptychura Beauchampi.
Dartmouth Dissertations

Characterization of the monosaccharide transport system of the thioglycollate-elicited mouse peritoneal macrophage and in vitro actions of glucocorticoids on macrophage growth, glucose metabolism, and monosaccharide transport
Glucose -- Metabolism. Macrophages. Glucocorticoids. Mice
Dartmouth Dissertations

Characterization of two S. Cerevisiae genes implicated in mRNA export: RAT7, encoding a novel nuclear pore complex protein and NPL3, encoding a putative hnRNP protein.
Messenger RNA -- Genetic aspects. Proteins -- Synthesis -- Genetic aspects. Saccharomyces cerevisiae -- Genetics.
Dartmouth Dissertations

Investigation of dynamic sea ice processes in the Weddell Sea during 1992.
Sea ice -- Antarctica -- Weddell Sea.
Through a series of case studies, signal processing and statistical tools, analyses of dynamic sea ice processes of drift, deformation, and ice pack expansion and decay are investigated for the Weddell Sea region during 1992. Cavitating fluid (CAV)...
Dartmouth Dissertations

Apoptosis as a mechanism of cell death by anticancer agents.
Apoptosis. Antineoplastic agents.
Dartmouth Dissertations

Optical properties of some amorphous and crystalline Al Cu alloys.
Aluminum-copper alloys -- Optical properties. Optical films. Alloys -- Analysis.
Dartmouth Dissertations

Solution chemistry of a New Hampshire subalpine ecosystem.
Forest ecology -- New Hampshire. Solution (Chemistry).
Dartmouth Dissertations

Induced optical effects in germanium-doped silica glass.
Silica, Vitreous -- Optical properties.
Dartmouth Dissertations

Experimental observations of the beam-plasma
Plasma spectroscopy. Electron beams.
Dartmouth Dissertations

The occurrence of amino acid activating enzymes and transfer RNA in rat liver mitochondria.
Mitochondria. Enzymes. ; Rats.
Dartmouth Dissertations

The effects of size dichopticity on the perception of depth.
Depth perception.
Dartmouth Dissertations

Stratigraphy, structure, and petrology of the Peterborough 15-minute quadrangle, New Hampshire; and Part II. Graphite textural and isotopic variations in plutonic rocks, south-central New Hampshire.
Geology -- New Hampshire -- Peterborough Quadrangle. Geology Stratigraphic. Geology.
Dartmouth Dissertations

From target discovery to high-throughput screens--selective CAL PDZ inhibitors as candidate CF therapeutics
Peptides -- Therapeutic use. ; Chloride channels -- Pathophysiology. ; Ligands (Biochemistry) ; Protein-protein interactions. ; Cystic fibrosis -- Molecular aspects. ; High throughput screening (Drug development) ; PDZ Domains. ; Cystic Fibrosis...
PDZ domains are protein:protein interaction domains that serve as molecular scaffolds, especially in the case of specialized cellular environments like polarized airway epithelial cells of the human lung. Historically the domains have been thought...
Dartmouth Dissertations

A generalized least-squares minimization method for near infrared diffuse optical tomography.
Optical tomography. ; Near infrared spectroscopy. ; Image analysis -- Mathematical models. ; Imaging systems -- Image quality -- Mathematical models. ; Image reconstruction -- Mathematical models. ; Least squares. Breast -- Tomography.
Diffuse optical tomography (DOT) has the potential to become a non-invasive and non-ionizing diagnostic imaging technique for breast cancer imaging. DOT uses near-infrared (NIR) light to illuminate the breast, generally through the use of fiber...
Dartmouth Dissertations

Allosteric modulation of GABAa receptors by anabolic-androgenic steroids.
GABA -- Receptors. Allosteric regulation. ; Anabolic steroids -- Physiological effect. ; Androgens -- Physiological effect. ; Receptors
Anabolic-androgenic steroids (AAS) are synthetic derivatives of the gonadal hormone, testosterone. Despite their many untoward side effects, AAS are wildly abused for their ergogenic properties. AAS have numerous effects on many organ systems,...
Dartmouth Dissertations

Mapping the junction of action perception and production.
Perceptual-motor learning -- Physiological aspects. ; Language acquisition -- Physiological aspects. ; Motor ability -- Physiological aspects. ; Knots and splices.
The studies presented in this dissertation explore several points of intersection between action perception and production within the human brain. One's ability to use perceptual information about another individual's actions to guide and inform...
Dartmouth Dissertations

Theory of surface impedance resonances in superconductors.
Superconductors.
Dartmouth Dissertations

An EPR spectroscopic investigation of paramagnetic organometallic complexes.
Organometallic compounds. ; Paramagnetism. ; Electron paramagnetic resonance spectroscopy.
Dartmouth Dissertations

Investigation of the reactivity of vinylimidazoles.
Imidazoles. ; Heterocyclic compounds -- Synthesis.
Dartmouth Dissertations

The in vitro generation and long-term culture of tumor-specific cytotoxic T-lymphocytes
Mouse leukemia viruses. ; Lymphocytes. ; T cells.
Dartmouth Dissertations

Electrostatic waves in an inhomogeneous plasma.
Plasma waves.
Dartmouth Dissertations

Restraint and disinhibition in the brain.
Self-control -- Physiological aspects. Nucleus accumbens -- Psychophysiology. Reducing diets -- Psychological aspects. Eating disorders -- Psychological aspects. Promiscuity -- Psychological aspects.
As humans we create goals and strive toward ideals, engaging in a constant endeavor to better ourselves or maintain our success. Whether goals are distant hopes for the future, or small steps of change, success requires some control over...
Dartmouth Dissertations

Neuronal interferon signaling : implications for HSV-1 replication and pathogenesis / by Pamela Rosato
Herpes simplex virus-1 (HSV-1) establishes lifelong latent infections in the sensory neurons of the trigeminal ganglia (TG) wherein it retains the capacity to reactivate. The interferon (IFN)-driven antiviral response is critical for the control of...
Dartmouth Dissertations

Multiplicative problems in combinatorial number theory / by Nathan McNew
In this thesis we look at several problems that lie in the intersection between combinatorial and multiplicative number theory. A common theme of many of these problems are estimates for and properties of the smooth numbers, those integers not...
Dartmouth Dissertations

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